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    RHOBTB1 Rho related BTB domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 9886, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RHOBTB1provided by HGNC
    Official Full Name
    Rho related BTB domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18738
    See related
    Ensembl:ENSG00000072422 MIM:607351; AllianceGenome:HGNC:18738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Expression
    Broad expression in placenta (RPKM 10.3), kidney (RPKM 7.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RHOBTB1 in Genome Data Viewer
    Location:
    10q21.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (60860860..61001967, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (61726193..61858729, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (62629196..62761198, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:62495900-62496400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:62496401-62496901 Neighboring gene ANK3 divergent transcript Neighboring gene cyclin dependent kinase 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:62629619-62630120 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:62630121-62630620 Neighboring gene uncharacterized LOC124902432 Neighboring gene RNA, U2 small nuclear 72, pseudogene Neighboring gene uncharacterized LOC124902431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2391 Neighboring gene uncharacterized LOC107984236 Neighboring gene Sharpr-MPRA regulatory region 5027 Neighboring gene uncharacterized LOC124902433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3395 Neighboring gene MPRA-validated peak951 silencer Neighboring gene long intergenic non-protein coding RNA 845 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:62795847-62796395 Neighboring gene uncharacterized LOC124902434

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B. McKinnon CM, et al. BMC Cancer, 2017 Feb 20. PMID 28219369, Free PMC Article
    2. Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. Beder LB, et al. J Cancer Res Clin Oncol, 2006 Jan. PMID 16170569
    3. Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination. Kumar G, et al. Function (Oxf), 2023. PMID 37575477, Free PMC Article
    4. The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. Xu RS, et al. Int J Oncol, 2013 Feb. PMID 23258531
    5. RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells. Long M, et al. Cells, 2020 Apr 28. PMID 32354068, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.
      Title: Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.
    2. RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.
      Title: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.
    3. RhoBTB1 associates with ROCK1 and ROCK2 and its association with ROCK1 is via its Rho domain.
      Title: RhoBTB1 interacts with ROCKs and inhibits invasion.
    4. RhoBTB1 regulates the integrity of the Golgi complex through METTL7B. RhoBTB1 is required for expression of METTL7B and silencing of either protein leads to fragmentation of the Golgi. Loss of RhoBTB1 expression is linked to Golgi fragmentation in breast cancer cells. Restoration of normal RhoBTB1 expression rescues Golgi morphology and dramatically inhibits breast cancer cell invasion.
      Title: The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.
    5. we found that miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.
      Title: The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    7. Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma).
      Title: Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0740, MGC33059, MGC33841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242359.2 → NP_001229288.1  rho-related BTB domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001229288.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same protein.
      Source sequence(s)
      AB018283, BC032848, BU624790, DA830304
      Consensus CDS
      CCDS7261.1
      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    2. NM_001350902.2 → NP_001337831.1  rho-related BTB domain-containing protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB018283, AK075129, BC041791, BQ574439
      Consensus CDS
      CCDS7261.1
      UniProtKB/Swiss-Prot
      O94844
      Related
      ENSP00000350595.4, ENST00000357917.4
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    3. NM_001350903.2 → NP_001337832.1  rho-related BTB domain-containing protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB018283, AC011197, BE046002, BQ574439, DA859805, DR004641
      Consensus CDS
      CCDS7261.1
      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    4. NM_001350904.2 → NP_001337833.1  rho-related BTB domain-containing protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB018283, BC032848, BU624790, BX389628, DA830304, DR002604
      Consensus CDS
      CCDS7261.1
      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    5. NM_001350905.2 → NP_001337834.1  rho-related BTB domain-containing protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB018283, BC032848, BU624790, DA793865, DA830304, DR002604
      Consensus CDS
      CCDS7261.1
      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    6. NM_001350906.2 → NP_001337835.1  rho-related BTB domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB018283, AC011197, AC027678, BE046002, BQ574439, DA859805, DR004641
      Conserved Domains (3) summary
      smart00225
      Location:276 → 335
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:356 → 461
      BTB; BTB/POZ domain
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. NM_001350907.2 → NP_001337836.1  rho-related BTB domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB018283, AC027678, BQ574439, DA781491, DR004641
      Conserved Domains (3) summary
      smart00225
      Location:276 → 335
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:356 → 461
      BTB; BTB/POZ domain
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    8. NM_001350908.2 → NP_001337837.1  rho-related BTB domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB018283, AC011197, AC027678, BE046002, BQ574439, DA859805, DR004641
      Conserved Domains (3) summary
      smart00225
      Location:276 → 335
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:356 → 461
      BTB; BTB/POZ domain
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    9. NM_001350909.2 → NP_001337838.1  rho-related BTB domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB018283, AC027678, AI935070, BC032848, BQ574439, DA930841, DR004641
      Conserved Domains (3) summary
      smart00225
      Location:276 → 335
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:356 → 461
      BTB; BTB/POZ domain
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    10. NM_001350910.2 → NP_001337839.1  rho-related BTB domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB018283, BC032848, BQ574439, DA930841, DR002604, DR004641
      Conserved Domains (3) summary
      smart00225
      Location:276 → 335
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:356 → 461
      BTB; BTB/POZ domain
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. NM_001350911.2 → NP_001337840.1  rho-related BTB domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB018283, AC027678, BQ574439, DA793865, DA930841, DR004641
      Conserved Domains (3) summary
      smart00225
      Location:276 → 335
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:356 → 461
      BTB; BTB/POZ domain
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    12. NM_014836.5 → NP_055651.1  rho-related BTB domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform. Variants 1-6 encode the same protein (isoform 1).
      Source sequence(s)
      AB018283, BC041791, BQ574439, DB453441
      Consensus CDS
      CCDS7261.1
      UniProtKB/Swiss-Prot
      O94844
      Related
      ENSP00000338671.5, ENST00000337910.10
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      60860860..61001967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426080.1 → XP_047282036.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    2. XM_047426086.1 → XP_047282042.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    3. XM_047426099.1 → XP_047282055.1  rho-related BTB domain-containing protein 1 isoform X2

    4. XM_047426092.1 → XP_047282048.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    5. XM_024448271.2 → XP_024304039.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    6. XM_011540425.2 → XP_011538727.1  rho-related BTB domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:17 → 208
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:486 → 583
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:476 → 578
      BTB; BTB/POZ domain
      cl02518
      Location:406 → 453
      BTB; BTB/POZ domain

    7. XM_011540424.2 → XP_011538726.1  rho-related BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538726.1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    8. XM_024448270.2 → XP_024304038.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    9. XM_047426083.1 → XP_047282039.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    10. XM_006718085.2 → XP_006718148.1  rho-related BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006718148.1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    11. XM_047426088.1 → XP_047282044.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    12. XM_047426082.1 → XP_047282038.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    13. XM_047426077.1 → XP_047282033.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    14. XM_047426078.1 → XP_047282034.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    15. XM_047426098.1 → XP_047282054.1  rho-related BTB domain-containing protein 1 isoform X2

    16. XM_047426095.1 → XP_047282051.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    17. XM_047426087.1 → XP_047282043.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    18. XM_047426091.1 → XP_047282047.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    19. XM_024448272.2 → XP_024304040.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    20. XM_047426097.1 → XP_047282053.1  rho-related BTB domain-containing protein 1 isoform X2

    21. XM_047426094.1 → XP_047282050.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    22. XM_047426074.1 → XP_047282030.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    23. XM_017017002.3 → XP_016872491.1  rho-related BTB domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:17 → 208
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:486 → 583
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:476 → 578
      BTB; BTB/POZ domain
      cl02518
      Location:406 → 453
      BTB; BTB/POZ domain

    24. XM_047426081.1 → XP_047282037.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    25. XM_047426096.1 → XP_047282052.1  rho-related BTB domain-containing protein 1 isoform X2

    26. XM_047426089.1 → XP_047282045.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    27. XM_047426090.1 → XP_047282046.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    28. XM_047426084.1 → XP_047282040.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    29. XM_047426075.1 → XP_047282031.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    30. XM_047426076.1 → XP_047282032.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    31. XM_047426093.1 → XP_047282049.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    32. XM_017017000.3 → XP_016872489.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    33. XM_047426079.1 → XP_047282035.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    34. XM_024448273.2 → XP_024304041.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18355
      Location:248 → 460
      BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18358
      Location:465 → 590
      BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cd18530
      Location:593 → 692
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

    35. XM_047426100.1 → XP_047282056.1  rho-related BTB domain-containing protein 1 isoform X3

    36. XM_011540428.2 → XP_011538730.1  rho-related BTB domain-containing protein 1 isoform X4

      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:17 → 208
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:396 → 455
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:406 → 453
      BTB; BTB/POZ domain

    37. XM_047426103.1 → XP_047282059.1  rho-related BTB domain-containing protein 1 isoform X4

    38. XM_047426104.1 → XP_047282060.1  rho-related BTB domain-containing protein 1 isoform X4

    39. XM_047426105.1 → XP_047282061.1  rho-related BTB domain-containing protein 1 isoform X4

    40. XM_047426102.1 → XP_047282058.1  rho-related BTB domain-containing protein 1 isoform X4

    RNA

    1. XR_007062022.1 RNA Sequence

    2. XR_007062020.1 RNA Sequence

    3. XR_007062021.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      61726193..61858729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367310.1 → XP_054223285.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    2. XM_054367326.1 → XP_054223301.1  rho-related BTB domain-containing protein 1 isoform X2

    3. XM_054367316.1 → XP_054223291.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    4. XM_054367303.1 → XP_054223278.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    5. XM_054367323.1 → XP_054223298.1  rho-related BTB domain-containing protein 1 isoform X2

    6. XM_054367307.1 → XP_054223282.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    7. XM_054367312.1 → XP_054223287.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    8. XM_054367324.1 → XP_054223299.1  rho-related BTB domain-containing protein 1 isoform X2

    9. XM_054367296.1 → XP_054223271.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    10. XM_054367300.1 → XP_054223275.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    11. XM_054367301.1 → XP_054223276.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    12. XM_054367302.1 → XP_054223277.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    13. XM_054367299.1 → XP_054223274.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    14. XM_054367314.1 → XP_054223289.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    15. XM_054367308.1 → XP_054223283.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    16. XM_054367329.1 → XP_054223304.1  rho-related BTB domain-containing protein 1 isoform X2

    17. XM_054367322.1 → XP_054223297.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    18. XM_054367313.1 → XP_054223288.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    19. XM_054367318.1 → XP_054223293.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    20. XM_054367297.1 → XP_054223272.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    21. XM_054367328.1 → XP_054223303.1  rho-related BTB domain-containing protein 1 isoform X2

    22. XM_054367319.1 → XP_054223294.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    23. XM_054367295.1 → XP_054223270.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    24. XM_054367311.1 → XP_054223286.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    25. XM_054367320.1 → XP_054223295.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    26. XM_054367306.1 → XP_054223281.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    27. XM_054367325.1 → XP_054223300.1  rho-related BTB domain-containing protein 1 isoform X2

    28. XM_054367321.1 → XP_054223296.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    29. XM_054367327.1 → XP_054223302.1  rho-related BTB domain-containing protein 1 isoform X2

    30. XM_054367315.1 → XP_054223290.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    31. XM_054367317.1 → XP_054223292.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    32. XM_054367309.1 → XP_054223284.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    33. XM_054367298.1 → XP_054223273.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    34. XM_054367304.1 → XP_054223279.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    35. XM_054367305.1 → XP_054223280.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94844

    36. XM_054367330.1 → XP_054223305.1  rho-related BTB domain-containing protein 1 isoform X3

    37. XM_054367331.1 → XP_054223306.1  rho-related BTB domain-containing protein 1 isoform X4

    38. XM_054367332.1 → XP_054223307.1  rho-related BTB domain-containing protein 1 isoform X4

    39. XM_054367334.1 → XP_054223309.1  rho-related BTB domain-containing protein 1 isoform X4

    40. XM_054367335.1 → XP_054223310.1  rho-related BTB domain-containing protein 1 isoform X4

    41. XM_054367333.1 → XP_054223308.1  rho-related BTB domain-containing protein 1 isoform X4

    RNA

    1. XR_008488314.1 RNA Sequence

    2. XR_008488315.1 RNA Sequence

    3. XR_008488316.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94844.2 GenPept UniProtKB/Swiss-Prot:O94844

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