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    EMP24 Emp24p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMP24
    Official Full Name
    Emp24p
    Primary source
    SGD:S000003168
    Locus tag
    YGL200C
    See related
    AllianceGenome:SGD:S000003168; FungiDB:YGL200C; VEuPathDB:YGL200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BST2
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein retention in ER lumen; and vesicle organization. Located in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum. Orthologous to several human genes including TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMP24 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (122694..123305, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene MCM DNA helicase complex subunit MCM6 Neighboring gene tRNA-Lys Neighboring gene Yip4p Neighboring gene Mds3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. Schimmöller F, et al. EMBO J, 1995 Apr 3. PMID 7729411, Free PMC Article
    2. Identification of potential regulatory elements for the transport of Emp24p. Nakamura N, et al. Mol Biol Cell, 1998 Dec. PMID 9843583, Free PMC Article
    3. Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport. Belden WJ, et al. J Biol Chem, 1996 Oct 25. PMID 8900179
    4. Identification of a lumenal sequence specifying the assembly of Emp24p into p24 complexes in the yeast secretory pathway. Ciufo LF, et al. J Biol Chem, 2000 Mar 24. PMID 10722670
    5. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. Muñiz M, et al. J Cell Biol, 2000 Mar 6. PMID 10704443, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emp24p
    NP_011315.3
    • Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      122694..123305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181065.3 → NP_011315.3  TPA: Emp24p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011315.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTV4, P32803
      UniProtKB/TrEMBL
      A6ZTY9, B3LHP8, B5VID3, C7GWZ5, G2WDQ7, N1PA01
      Conserved Domains (1) summary
      pfam01105
      Location:20 → 198
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32803.1

    Gene LinkOut

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