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    Dnah11 dynein, axonemal, heavy chain 11 [ Mus musculus (house mouse) ]

    Gene ID: 13411, updated on 27-Dec-2024

    Summary

    Official Symbol
    Dnah11provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 11provided by MGI
    Primary source
    MGI:MGI:1100864
    See related
    Ensembl:ENSMUSG00000018581 AllianceGenome:MGI:1100864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    iv; lrd; avc4; Dnahc11; b2b598Clo; b2b1203Clo; b2b1279Clo; b2b1289Clo; b2b1727Clo
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within several processes, including cardiac septum morphogenesis; determination of left/right symmetry; and flagellated sperm motility. Located in 9+0 motile cilium; 9+2 motile cilium; and proximal portion of axoneme. Is expressed in several structures, including future brain; node; oviduct; respiratory system; and secondary heart field. Used to study Kartagener syndrome; atrioventricular septal defect; primary ciliary dyskinesia 7; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 1.1), cerebellum adult (RPKM 1.0) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Dnah11 in Genome Data Viewer
    Location:
    12 F2; 12 63.25 cM
    Exon count:
    86
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (117841717..118162778, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (117877982..118199043, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 5 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119003289-119003590 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:119058566-119058867 Neighboring gene STARR-seq mESC enhancer starr_33427 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene STARR-seq mESC enhancer starr_33429 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119539914-119540215 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119540362-119540663 Neighboring gene trans-acting transcription factor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:119611733-119611916 Neighboring gene STARR-seq mESC enhancer starr_33430 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:119615690-119615886 Neighboring gene predicted gene, 25577

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding  
    enables dynein light intermediate chain binding  
    enables minus-end-directed microtubule motor activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac septum morphogenesis PubMed 
    acts_upstream_of_or_within cilium movement PubMed 
    involved_in cilium movement involved in cell motility  
    acts_upstream_of_or_within determination of left/right asymmetry in nervous system PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within determination of left/right symmetry  
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry PubMed 
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement PubMed 
    acts_upstream_of_or_within flagellated sperm motility PubMed 
    acts_upstream_of_or_within flagellated sperm motility  
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within learning or memory PubMed 
    acts_upstream_of_or_within regulation of cilium beat frequency  
    Component Evidence Code Pubs
    located_in 9+0 motile cilium PubMed 
    is_active_in 9+2 motile cilium  
    located_in 9+2 motile cilium PubMed 
    is_active_in axoneme  
    located_in axoneme PubMed 
    located_in axoneme  
    located_in cilium PubMed 
    part_of dynein complex  
    located_in motile cilium PubMed 
    located_in motile cilium  
    located_in proximal portion of axoneme PubMed 

    General protein information

    Preferred Names
    dynein axonemal heavy chain 11
    Names
    dynein, axon, heavy chain 11
    situs inversus viscerum

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010060.3NP_034190.3  dynein axonemal heavy chain 11

      Status: VALIDATED

      Source sequence(s)
      AC139993, AC163032, AC163278, AC163688, AC167979
      Consensus CDS
      CCDS36578.1
      UniProtKB/TrEMBL
      E9Q7N9, Q9QZH1
      Related
      ENSMUSP00000081867.7, ENSMUST00000084806.7
      Conserved Domains (2) summary
      COG5245
      Location:15244138
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:30693413
      MT; Microtubule-binding stalk of dynein motor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      117841717..118162778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314946.3XP_017170435.1  dynein axonemal heavy chain 11 isoform X1

      Conserved Domains (6) summary
      COG5245
      Location:1542727
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:16992043
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:3332
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:466792
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:14271686
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:27803075
      Dynein_C; Dynein heavy chain C-terminal domain
    2. XM_017314947.3XP_017170436.1  dynein axonemal heavy chain 11 isoform X2

      Conserved Domains (6) summary
      COG5245
      Location:1542710
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:16411985
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:3332
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:466792
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:13691628
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:27633058
      Dynein_C; Dynein heavy chain C-terminal domain
    3. XM_006515463.5XP_006515526.1  dynein axonemal heavy chain 11 isoform X3

      Conserved Domains (5) summary
      COG5245
      Location:51935
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:8661210
      MT; Microtubule-binding stalk of dynein motor
      pfam12780
      Location:594853
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:12371450
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:19882283
      Dynein_C; Dynein heavy chain C-terminal domain
    4. XM_006515464.4XP_006515527.1  dynein axonemal heavy chain 11 isoform X5

      Conserved Domains (8) summary
      pfam12777
      Location:487831
      MT; Microtubule-binding stalk of dynein motor
      pfam03028
      Location:13261442
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12780
      Location:215474
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:8581071
      AAA_9; ATP-binding dynein motor region D5
      pfam17857
      Location:72169
      AAA_lid_1; AAA+ lid domain
      pfam18198
      Location:14441603
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:16091904
      Dynein_C; Dynein heavy chain C-terminal domain
      cl38985
      Location:139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    5. XM_006515466.5XP_006515529.1  dynein axonemal heavy chain 11 isoform X6

      Conserved Domains (6) summary
      pfam12777
      Location:53397
      MT; Microtubule-binding stalk of dynein motor
      pfam03028
      Location:8921008
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12781
      Location:424637
      AAA_9; ATP-binding dynein motor region D5
      pfam18198
      Location:10101169
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:11751470
      Dynein_C; Dynein heavy chain C-terminal domain
      cl38985
      Location:140
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. XM_006515468.3XP_006515531.1  dynein axonemal heavy chain 11 isoform X8

      Conserved Domains (4) summary
      pfam03028
      Location:448564
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12781
      Location:35193
      AAA_9; ATP-binding dynein motor region D5
      pfam18198
      Location:566725
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:7311026
      Dynein_C; Dynein heavy chain C-terminal domain
    7. XM_006515467.3XP_006515530.1  dynein axonemal heavy chain 11 isoform X7

      Conserved Domains (4) summary
      pfam03028
      Location:541657
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12781
      Location:73286
      AAA_9; ATP-binding dynein motor region D5
      pfam18198
      Location:659818
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:8241119
      Dynein_C; Dynein heavy chain C-terminal domain
    8. XM_017314949.1XP_017170438.1  dynein axonemal heavy chain 11 isoform X4

      Conserved Domains (9) summary
      pfam12777
      Location:16992043
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:3332
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:466792
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:10731251
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:14271686
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:20702234
      AAA_9; ATP-binding dynein motor region D5
      pfam17852
      Location:9511068
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam17857
      Location:12841381
      AAA_lid_1; AAA+ lid domain
      cl38936
      Location:780915
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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