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    Plcd4 phospholipase C, delta 4 [ Mus musculus (house mouse) ]

    Gene ID: 18802, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plcd4provided by MGI
    Official Full Name
    phospholipase C, delta 4provided by MGI
    Primary source
    MGI:MGI:107469
    See related
    Ensembl:ENSMUSG00000026173 AllianceGenome:MGI:107469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921507K24Rik
    Summary
    Predicted to enable G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol phospholipase C activity. Acts upstream of or within acrosome reaction. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in plasma membrane. Is expressed in male reproductive gland or organ and nervous system. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 22.6), cerebellum adult (RPKM 4.2) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Plcd4 in Genome Data Viewer
    Location:
    1 C4; 1 38.54 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74581175..74605137)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74541975..74565977)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene zinc finger protein 142 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding  
    enables G-protein alpha-subunit binding  
    enables calcium ion binding  
    enables guanyl-nucleotide exchange factor activity  
    enables phosphatidylinositol phospholipase C activity  
    enables phosphatidylinositol phospholipase C activity  
    enables phosphatidylinositol phospholipase C activity  
    enables phospholipase C activity PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in intracellular anatomical structure PubMed 
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Names
    PLC-delta-4
    phosphoinositide phospholipase C-delta-4
    NP_001074925.1
    NP_683739.2
    XP_006495846.1
    XP_006495847.1
    XP_006495848.1
    XP_006495850.1
    XP_006495851.1
    XP_006495852.1
    XP_017174835.1
    XP_036018673.1
    XP_036018674.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081456.1NP_001074925.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35617.1
      UniProtKB/Swiss-Prot
      Q8K3R3
      Related
      ENSMUSP00000109376.2, ENSMUST00000113747.8
      Conserved Domains (8) summary
      cd00275
      Location:639764
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02228
      Location:207752
      PLN02228; Phosphoinositide phospholipase C
      pfam00169
      Location:17123
      PH; PH domain
      pfam09279
      Location:207289
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:143199
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289609
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain
    2. NM_148937.2NP_683739.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2

      See identical proteins and their annotated locations for NP_683739.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is longer but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35616.1
      UniProtKB/Swiss-Prot
      Q3USN9, Q6NZF7, Q8CAB1, Q8K3R3, Q9CUC1
      Related
      ENSMUSP00000027362.8, ENSMUST00000027362.14
      Conserved Domains (4) summary
      PLN02228
      Location:207784
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74581175..74605137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495787.5XP_006495850.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

      Conserved Domains (4) summary
      PLN02228
      Location:207772
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289640
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    2. XM_006495785.5XP_006495848.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006495848.1

      Conserved Domains (4) summary
      PLN02228
      Location:207773
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    3. XM_006495783.5XP_006495846.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006495846.1

      Conserved Domains (4) summary
      PLN02228
      Location:207773
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    4. XM_036162781.1XP_036018674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

      Conserved Domains (4) summary
      PLN02228
      Location:207740
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289608
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain
    5. XM_036162780.1XP_036018673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4

      Conserved Domains (4) summary
      PLN02228
      Location:207783
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289640
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain
    6. XM_006495789.5XP_006495852.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

      Conserved Domains (4) summary
      PLN02228
      Location:207741
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289609
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain
    7. XM_006495788.5XP_006495851.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3

      See identical proteins and their annotated locations for XP_006495851.1

      UniProtKB/Swiss-Prot
      Q3USN9, Q6NZF7, Q8CAB1, Q8K3R3, Q9CUC1
      Conserved Domains (4) summary
      PLN02228
      Location:207784
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain
    8. XM_017319346.3XP_017174835.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7

      Conserved Domains (4) summary
      PLN02228
      Location:207751
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289608
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18133
      PH-like; Pleckstrin homology-like domain
    9. XM_006495784.5XP_006495847.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006495847.1

      Conserved Domains (4) summary
      PLN02228
      Location:207773
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153202
      EF-hand_10; EF hand
      cl14615
      Location:289641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RNA

    1. XR_865222.4 RNA Sequence

    2. XR_001783208.3 RNA Sequence

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