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    Pou3f3 POU domain, class 3, transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 18993, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pou3f3provided by MGI
    Official Full Name
    POU domain, class 3, transcription factor 3provided by MGI
    Primary source
    MGI:MGI:102564
    See related
    Ensembl:ENSMUSG00000045515 AllianceGenome:MGI:102564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brn1; Otf8; Brn-1; Skin1; HST011; urehr2
    Summary
    Enables HMG box domain binding activity and sequence-specific DNA binding activity. Involved in several processes, including metanephric nephron epithelium development; negative regulation of apoptotic process; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including forebrain development; positive regulation of transcription by RNA polymerase II; and urea transmembrane transport. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; phalanx; and sensory organ. Orthologous to human POU3F3 (POU class 3 homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pou3f3 in Genome Data Viewer
    Location:
    1 B; 1 21.21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (42734928..42739370)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (42695768..42700210)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36822 Neighboring gene POU domain, class 3, transcription factor 3 adjacent noncoding transcript 1 Neighboring gene predicted gene 20646 Neighboring gene RIKEN cDNA 2900092D14 gene Neighboring gene POU domain, class 3, transcription factor 3 adjacent noncoding transcript 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration PubMed 
    acts_upstream_of_or_within chemical homeostasis PubMed 
    acts_upstream_of_or_within forebrain ventricular zone progenitor cell division PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    involved_in metanephric DCT cell differentiation PubMed 
    involved_in metanephric ascending thin limb development PubMed 
    involved_in metanephric loop of Henle development PubMed 
    involved_in metanephric macula densa development PubMed 
    involved_in metanephric thick ascending limb development PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within urea transmembrane transport PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    POU domain, class 3, transcription factor 3
    Names
    OTF-8
    brain-1
    brain-specific homeobox/POU domain protein 1
    oct-8
    octamer-binding protein 8
    octamer-binding transcription factor 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008900.3NP_032926.2  POU domain, class 3, transcription factor 3

      See identical proteins and their annotated locations for NP_032926.2

      Status: VALIDATED

      Source sequence(s)
      AC122898
      Consensus CDS
      CCDS14917.1
      UniProtKB/Swiss-Prot
      P31361
      Related
      ENSMUSP00000052088.3, ENSMUST00000054883.4
      Conserved Domains (2) summary
      smart00352
      Location:311385
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:406460
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      42734928..42739370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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