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    Arl13b ADP-ribosylation factor-like 13B [ Mus musculus (house mouse) ]

    Gene ID: 68146, updated on 17-Dec-2024

    Summary

    Official Symbol
    Arl13bprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 13Bprovided by MGI
    Primary source
    MGI:MGI:1915396
    See related
    Ensembl:ENSMUSG00000022911 AllianceGenome:MGI:1915396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hnn; Arl2l1; A530097K21Rik; A930014M17Rik; C530009C10Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in nervous system development; non-motile cilium assembly; and smoothened signaling pathway. Acts upstream of or within dorsal/ventral pattern formation; heart looping; and left/right axis specification. Located in axoneme; ciliary membrane; and motile cilium. Is expressed in several structures, including chordamesoderm; embryo mesenchyme; gonad; neural ectoderm; and node. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ADP ribosylation factor like GTPase 13B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.6), testis adult (RPKM 3.9) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arl13b in Genome Data Viewer
    Location:
    16 C1.3; 16 36.43 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (62613671..62667418, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (62793308..62847055, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41128 Neighboring gene NOL1/NOP2/Sun domain family member 3 Neighboring gene predicted gene, 52231 Neighboring gene STARR-positive B cell enhancer ABC_E7471 Neighboring gene syntaxin 19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:62846895-62847078 Neighboring gene STARR-seq mESC enhancer starr_41130 Neighboring gene STARR-seq mESC enhancer starr_41131 Neighboring gene protein S (alpha) Neighboring gene STARR-positive B cell enhancer mm9_chr16:62940376-62940676 Neighboring gene STARR-seq mESC enhancer starr_41132 Neighboring gene predicted gene, 53931

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in axoneme PubMed 
    is_active_in ciliary membrane  
    located_in ciliary membrane PubMed 
    located_in cilium PubMed 
    located_in cilium PubMed 
    located_in cilium  
    located_in cytosol  
    is_active_in motile cilium  
    located_in motile cilium PubMed 
    is_active_in non-motile cilium  

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 13B
    Names
    ADP-ribosylation factor-like 2-like 1
    ARL2-like protein 1
    protein hennin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026577.4NP_080853.3  ADP-ribosylation factor-like protein 13B

      See identical proteins and their annotated locations for NP_080853.3

      Status: VALIDATED

      Source sequence(s)
      AC154309, AK016794, AK021270, CF741686
      Consensus CDS
      CCDS28261.1
      UniProtKB/Swiss-Prot
      G3X9K5, Q640N2
      Related
      ENSMUSP00000086703.6, ENSMUST00000089289.6
      Conserved Domains (2) summary
      cd04161
      Location:23189
      Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
      pfam00071
      Location:24172
      Ras; Ras family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      62613671..62667418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522504.4XP_006522567.1  ADP-ribosylation factor-like protein 13B isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:186
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_006522505.5XP_006522568.1  ADP-ribosylation factor-like protein 13B isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:2182
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006522503.5XP_006522566.1  ADP-ribosylation factor-like protein 13B isoform X1

      Conserved Domains (1) summary
      cd04161
      Location:23189
      Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
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