Hook3 hook microtubule tethering protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hook3provided by MGI
Official Full Name: hook microtubule tethering protein 3provided by MGI
Primary source: MGI:MGI:2443554
See related: Ensembl:ENSMUSG00000037234 AllianceGenome:MGI:2443554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5830454D03Rik; E330005F07Rik
Summary: Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in interkinetic nuclear migration; negative regulation of neurogenesis; and protein localization to centrosome. Acts upstream of or within microtubule anchoring at centrosome and neuronal stem cell population maintenance. Located in centriolar satellite; cytoplasm; and pericentriolar material. Is expressed in central nervous system; future brain; and genitourinary system. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 5.4), whole brain E14.5 (RPKM 5.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 14.29 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (26511449..26609646, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (26021421..26119618, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2).
Title: Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.
Identified hook3 as the first cooperation partner of a member of the 47 kDa GTPase protein family (IIGP) and indicated that hook3 links in an IFNgamma-inducible fashion to cytoskeleton-based membrane trafficking.
Title: IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3.
Hook3 interacts with a cytoplasmic domain of scavenger receptor A
Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hook3 (e-PCR), detects polymorphism
- UniSTS:527390

AW743351 (e-PCR)
- UniSTS:208257

RH136156 (e-PCR)
- UniSTS:210151

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynactin binding	ISO Inferred from Sequence Orthology more info
enables dynactin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein light chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light chain binding	ISO Inferred from Sequence Orthology more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi localization	IEA Inferred from Electronic Annotation more info
involved_in Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule anchoring at centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
involved_in protein localization to perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of FHF complex	ISO Inferred from Sequence Orthology more info
part_of FHF complex	ISS Inferred from Sequence or Structural Similarity more info
part_of HOPS complex	IEA Inferred from Electronic Annotation more info
part_of HOPS complex	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein Hook homolog 3

Names: hook homolog 3; mHK3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207659.3 → NP_997542.1 protein Hook homolog 3

See identical proteins and their annotated locations for NP_997542.1

Status: VALIDATED

Source sequence(s)

AC093366

Consensus CDS

CCDS22206.1

UniProtKB/Swiss-Prot

Q540A0, Q8BUK6, Q8BV48, Q8BW57, Q8BY41

UniProtKB/TrEMBL

Q5BKS5

Related

ENSMUSP00000046788.8, ENSMUST00000037182.14

Conserved Domains (1) summary

pfam05622
Location:12 → 710

HOOK; HOOK protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

26511449..26609646 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509150.3 → XP_006509213.1 protein Hook homolog 3 isoform X3

UniProtKB/TrEMBL

Q5BKS5

Conserved Domains (1) summary

pfam05622
Location:12 → 669

HOOK; HOOK protein
XM_006509148.3 → XP_006509211.1 protein Hook homolog 3 isoform X1

UniProtKB/TrEMBL

Q5BKS5

Conserved Domains (1) summary

pfam05622
Location:12 → 712

HOOK; HOOK protein
XM_006509149.5 → XP_006509212.1 protein Hook homolog 3 isoform X2

UniProtKB/TrEMBL

Q5BKS5

Conserved Domains (1) summary

pfam05622
Location:12 → 676

HOOK; HOOK protein