Glud1 glutamate dehydrogenase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glud1provided by MGI
Official Full Name: glutamate dehydrogenase 1provided by MGI
Primary source: MGI:MGI:95753
See related: Ensembl:ENSMUSG00000021794 AllianceGenome:MGI:95753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glud; Gdh-X; Gludl
Summary: Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamine metabolic process and tricarboxylic acid metabolic process. Acts upstream of or within positive regulation of insulin secretion. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver adult (RPKM 291.2), liver E18 (RPKM 185.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.8 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (34032684..34066990)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (34310727..34345033)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.
Title: Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.
GluD1 binds GABA and controls inhibitory plasticity.
Title: GluD1 binds GABA and controls inhibitory plasticity.
Potentiation of neuronal activity by tonic GluD1 current in brain slices.
Title: Potentiation of neuronal activity by tonic GluD1 current in brain slices.
Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.
Title: Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.
GluD1 is a signal transduction device disguised as an ionotropic receptor.
Title: GluD1 is a signal transduction device disguised as an ionotropic receptor.
Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.
Title: Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.
Loss of GluD1 show impaired fear memory, social interaction, and enhanced depressive-like behavior.
Title: GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.
GluD1 defines a trans-synaptic interaction regulating postsynaptic signaling pathways for the proper establishment of cortical inhibitory connectivity
Title: Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.
we show that GDH is a crucial enzyme for neurons to metabolize glutamine-derived carbon in the tricarboxylic acid cycle during glucose deprivation
Title: Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.
Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI118167 (e-PCR)
- UniSTS:165901

PMC312732P3 (e-PCR)
- UniSTS:272911

GLUD1-1 (e-PCR)
- UniSTS:511772

DXS7028E (e-PCR)
- UniSTS:99109

Glud1 (e-PCR), detects polymorphism
- UniSTS:506939

46.MHAa90d10.seq (e-PCR)
- UniSTS:124607

GDB:277890 (e-PCR)
- UniSTS:156370

D16Mgh3 (e-PCR)
- UniSTS:239334

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables L-leucine binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutamate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables glutamate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables glutamate dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in glutamate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to aluminum ion	IEA Inferred from Electronic Annotation more info
involved_in response to aluminum ion	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate dehydrogenase 1, mitochondrial

Names: GDH 1

NP_032159.1

EC 1.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008133.4 → NP_032159.1 glutamate dehydrogenase 1, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AK089152, AK150637, AK161876

Consensus CDS

CCDS26935.1

UniProtKB/Swiss-Prot

P26443, Q8C273

Related

ENSMUSP00000022322.10, ENSMUST00000022322.17

Conserved Domains (1) summary

COG0334
Location:104 → 546

GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]