SNP1 U1 snRNP complex subunit SNP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNP1
Official Full Name: U1 snRNP complex subunit SNP1
Primary source: SGD:S000001323
Locus tag: YIL061C
See related: AllianceGenome:SGD:S000001323; FungiDB:YIL061C; VEuPathDB:YIL061C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables U1 snRNA binding activity and mRNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Used to study mixed connective tissue disease. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SNP1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (244657..245559, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BBP/Mud2 influences U1 binding at the 5' splice site by promoting long-lived E complex formation.
Title: Dynamics and consequences of spliceosome E complex formation.
The SNP1-(1-223) and SNP1-(1-208) truncation alleles restored the growth of tgs1Delta cells at different temperature.
Title: Two Routes to Genetic Suppression of RNA Trimethylguanosine Cap Deficiency via C-Terminal Truncation of U1 snRNP Subunit Snp1 or Overexpression of RNA Polymerase Subunit Rpo26.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U1 snRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	IDA Inferred from Direct Assay more info	PubMed
part_of U2-type prespliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type prespliceosome	IDA Inferred from Direct Assay more info	PubMed
part_of commitment complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: U1 snRNP complex subunit SNP1

NP_012203.1

Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1-70K, which has been linked to several types of autoimmune and neurodegenerative diseases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

244657..245559 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179411.1 → NP_012203.1 TPA: U1 snRNP complex subunit SNP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012203.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVM3, Q00916

UniProtKB/TrEMBL

A6ZVL2, C7GVY5, G2WG87

Conserved Domains (2) summary

pfam12220
Location:6 → 95

U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

cd21615
Location:89 → 201

RRM_SNP1_like; RNA recognition motif (RRM) found in Saccharomyces cerevisiae U1 small nuclear ribonucleoprotein SNP1 and similar proteins