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    Phf24 PHD finger protein 24 [ Mus musculus (house mouse) ]

    Gene ID: 230085, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Phf24provided by MGI
    Official Full Name
    PHD finger protein 24provided by MGI
    Primary source
    MGI:MGI:2140712
    See related
    Ensembl:ENSMUSG00000036062 AllianceGenome:MGI:2140712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GINIP
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of pain; gamma-aminobutyric acid signaling pathway; and regulation of GABAergic synaptic transmission. Is active in glutamatergic synapse and synaptic vesicle membrane. Is expressed in male reproductive gland or organ; nervous system; retina; and small intestine. Orthologous to human PHF24 (PHD finger protein 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 28.7), frontal lobe adult (RPKM 19.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phf24 in Genome Data Viewer
    Location:
    4 A5; 4 22.91 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42872619..42944752)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42872618..42944752)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene predicted gene 9615 Neighboring gene spermatogenesis associated 31 subfamily F member 1A Neighboring gene STARR-seq mESC enhancer starr_10042 Neighboring gene spermatogenesis associated 31 subfamily F member 3 Neighboring gene predicted gene, 52697 Neighboring gene STARR-positive B cell enhancer ABC_E660 Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene SPATA31 subfamily G member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peripheral nerve injury induces loss of nociceptive neuron-specific Gαi-interacting protein in neuropathic pain rat. Liu Z, et al. Mol Pain, 2016. PMID 27145804, Free PMC Article
    2. Neurochemical and Ultrastructural Characterization of Unmyelinated Non-peptidergic C-Nociceptors and C-Low Threshold Mechanoreceptors Projecting to Lamina II of the Mouse Spinal Cord. Salio C, et al. Cell Mol Neurobiol, 2021 Mar. PMID 32306148
    3. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Hoeffel G, et al. Nature, 2021 Jun. PMID 34012116
    4. Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits. Park JC, et al. Mol Cell, 2023 Jul 20. PMID 37390816, Free PMC Article
    5. GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Gaillard S, et al. Neuron, 2014 Oct 1. PMID 25242222, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GINIP is predominantly expressed by small nonpeptidergic nociceptive neurons and that nerve injury triggers loss of GINIP expression.
      Title: Peripheral nerve injury induces loss of nociceptive neuron-specific Gαi-interacting protein in neuropathic pain rat.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1045, A230025O18

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PHD finger protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346526.1 → NP_001333455.1  PHD finger protein 24 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Variants 1, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AL672276, AL772334, CJ250336
      Consensus CDS
      CCDS84719.1
      UniProtKB/Swiss-Prot
      A2AG28, Q80TL4, Q8BH08
      Conserved Domains (1) summary
      pfam16744
      Location:126 → 198
      Zf_RING; KIAA1045 RING finger

    2. NM_001355693.1 → NP_001342622.1  PHD finger protein 24 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AK045544, AK138412, AW456637, BC057092, BM944560, BY289608, BY289935, CA327828, CJ114289, CX243634
      Consensus CDS
      CCDS84719.1
      UniProtKB/Swiss-Prot
      A2AG28, Q80TL4, Q8BH08
      Related
      ENSMUSP00000103609.2, ENSMUST00000107975.8
      Conserved Domains (1) summary
      pfam16744
      Location:126 → 198
      Zf_RING; KIAA1045 RING finger

    3. NM_001355694.1 → NP_001342623.1  PHD finger protein 24 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AK045544, AK138412, AL672276, AW456637, BC057092, CJ107729
      Consensus CDS
      CCDS84719.1
      UniProtKB/Swiss-Prot
      A2AG28, Q80TL4, Q8BH08
      Conserved Domains (1) summary
      pfam16744
      Location:126 → 198
      Zf_RING; KIAA1045 RING finger

    4. NM_001355695.1 → NP_001342624.1  PHD finger protein 24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment, and is shorter, compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AK038528, AK045544, AK138412, AW456637, CJ107729
      Consensus CDS
      CCDS18083.1
      Related
      ENSMUSP00000071011.3, ENSMUST00000069184.9
      Conserved Domains (1) summary
      pfam16744
      Location:89 → 161
      Zf_RING; KIAA1045 RING finger

    5. NM_001374110.1 → NP_001361039.1  PHD finger protein 24 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 6 encode the same isoform (1)
      Source sequence(s)
      AL672276
      UniProtKB/Swiss-Prot
      A2AG28, Q80TL4, Q8BH08
      Conserved Domains (1) summary
      pfam16744
      Location:126 → 198
      Zf_RING; KIAA1045 RING finger

    6. NM_172690.3 → NP_766278.1  PHD finger protein 24 isoform 2

      See identical proteins and their annotated locations for NP_766278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment, and is shorter, compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AK045544, AK138412, AW456637, BC057092, CJ107729
      Consensus CDS
      CCDS18083.1
      UniProtKB/Swiss-Prot
      Q80TL4
      Related
      ENSMUSP00000103610.3, ENSMUST00000107976.9
      Conserved Domains (1) summary
      pfam16744
      Location:89 → 161
      Zf_RING; KIAA1045 RING finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      42872619..42944752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253408.2 → XP_030109268.1  PHD finger protein 24 isoform X2

      UniProtKB/Swiss-Prot
      A2AG28, Q80TL4, Q8BH08
      Conserved Domains (1) summary
      pfam16744
      Location:126 → 198
      Zf_RING; KIAA1045 RING finger

    2. XM_030253409.2 → XP_030109269.1  PHD finger protein 24 isoform X2

      UniProtKB/Swiss-Prot
      A2AG28, Q80TL4, Q8BH08
      Conserved Domains (1) summary
      pfam16744
      Location:126 → 198
      Zf_RING; KIAA1045 RING finger

    3. XM_030253410.2 → XP_030109270.1  PHD finger protein 24 isoform X4

      Conserved Domains (1) summary
      pfam16744
      Location:89 → 161
      Zf_RING; KIAA1045 RING finger

    4. XM_017320124.3 → XP_017175613.1  PHD finger protein 24 isoform X4

      UniProtKB/Swiss-Prot
      Q80TL4
      Conserved Domains (1) summary
      pfam16744
      Location:89 → 161
      Zf_RING; KIAA1045 RING finger

    5. XM_036163987.1 → XP_036019880.1  PHD finger protein 24 isoform X5

      UniProtKB/TrEMBL
      F6SBE4
      Conserved Domains (1) summary
      pfam16744
      Location:1 → 67
      Zf_RING; KIAA1045 RING finger

    6. XM_030253411.1 → XP_030109271.1  PHD finger protein 24 isoform X5

      UniProtKB/TrEMBL
      F6SBE4
      Conserved Domains (1) summary
      pfam16744
      Location:1 → 67
      Zf_RING; KIAA1045 RING finger

    7. XM_006537819.4 → XP_006537882.1  PHD finger protein 24 isoform X4

      See identical proteins and their annotated locations for XP_006537882.1

      UniProtKB/Swiss-Prot
      Q80TL4
      Conserved Domains (1) summary
      pfam16744
      Location:89 → 161
      Zf_RING; KIAA1045 RING finger

    8. XM_006537809.4 → XP_006537872.1  PHD finger protein 24 isoform X1

      Conserved Domains (1) summary
      pfam16744
      Location:157 → 229
      Zf_RING; KIAA1045 RING finger

    9. XM_017320123.3 → XP_017175612.1  PHD finger protein 24 isoform X3

      Conserved Domains (1) summary
      pfam16744
      Location:99 → 171
      Zf_RING; KIAA1045 RING finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TL4.2 GenPept UniProtKB/Swiss-Prot:Q80TL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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