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    Dlc90F Dynein light chain 90F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlc90Fprovided by FlyBase
    Official Full Name
    Dynein light chain 90Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024432
    Locus tag
    Dmel_CG12363
    See related
    AllianceGenome:FB:FBgn0024432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bs35g12.y1; CG12363; dlc90F; Dmel\CG12363; dtctex-1; Dynein; l(3)04091; tctex; Tctex; tctex-1; Tctex-1; TcTex-1; Tctex1
    Summary
    Enables several functions, including disordered domain specific binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Involved in determination of adult lifespan; retrograde axonal transport; and spermatid development. Part of dynein complex. Is expressed in several structures, including adult head; anterior endoderm; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to several human genes including DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dlc90F in Genome Data Viewer
    Location:
    91A2-91A2; 3-63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18299229..18300044)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14124951..14125766)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lethal (3) 05822 Neighboring gene RNA polymerase I subunit E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of dynein light chain TcTex-1. Williams JC, et al. J Biol Chem, 2005 Jun 10. PMID 15701632
    2. Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Williams JC, et al. Proc Natl Acad Sci U S A, 2007 Jun 12. PMID 17551010, Free PMC Article
    3. dtctex-1, the Drosophila melanogaster homolog of a putative murine t-complex distorter encoding a dynein light chain, is required for production of functional sperm. Caggese C, et al. Mol Genet Genomics, 2001 May. PMID 11405626
    4. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74. Makokha M, et al. Biochemistry, 2002 Apr 2. PMID 11914076
    5. Characterization of the cargo attachment complex of cytoplasmic dynein using NMR and mass spectrometry. Barbar E, et al. Methods Enzymol, 2004. PMID 15051340

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein light chain 1 is required for protein clearance by autophagy that is associated with autophagic cell death and neurodegeneration.
      Title: Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila.
    2. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74
      Title: Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74.
    3. Dlc90F is required for the localization of cytoplasmic dynein and is not essential for early development or in the adult organism.
      Title: The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation.
    4. x-ray crystallographic analysis of dynein light chain TcTex-1 structure
      Title: Crystal structure of dynein light chain TcTex-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dynein light intermediate chain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle HMP PubMed 
    involved_in retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein light chain 90F
    Names
    CG12363-PA
    Dlc90F-PA
    dynein light chain; tctex-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18299229..18300044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058008.4 → NP_477356.1  dynein light chain 90F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94524, Q9VE95
      UniProtKB/TrEMBL
      A0A1B2AIX7
      Related
      FBpp0082996
      Conserved Domains (1) summary
      cd21462
      Location:10 → 111
      DLC-like_DYNLT1; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94524.1 Q94524

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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