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    CAH7 Carbonic anhydrase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41238, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CAH7provided by FlyBase
    Official Full Name
    Carbonic anhydrase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0037788
    Locus tag
    Dmel_CG3940
    See related
    AllianceGenome:FB:FBgn0037788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3940; Dmel\CG3940
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; cuboidal/columnar epithelium; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CAH7 in Genome Data Viewer
    Location:
    85F12-85F13; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10112237..10120081)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5937959..5945803)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43459 Neighboring gene mir-34 stem loop Neighboring gene Fragile X messenger ribonucleoprotein 1 Neighboring gene ATP synthase, epsilon subunit-like Neighboring gene gamma Soluble NSF attachment protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Dockendorff TC, et al. Neuron, 2002 Jun 13. PMID 12086644
    2. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    3. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article
    4. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
    5. Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo. Deignan L, et al. PLoS Genet, 2016 Jul. PMID 27379389, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 7
    Names
    CAH7-PA
    CAH7-PB
    CAH7-PC
    CG3940-PA
    CG3940-PB
    CG3940-PC
    NP_001287267.1
    NP_001287268.1
    NP_649979.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10112237..10120081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300338.1 → NP_001287267.1  carbonic anhydrase 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH26
      Conserved Domains (1) summary
      cd00326
      Location:45 → 269
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_001300339.1 → NP_001287268.1  carbonic anhydrase 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH26
      Conserved Domains (1) summary
      cd00326
      Location:45 → 269
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. NM_141722.2 → NP_649979.1  carbonic anhydrase 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH26
      Related
      FBpp0081657
      Conserved Domains (1) summary
      cd00326
      Location:45 → 269
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS01 Q8MS01
    Q9VH26 Q9VH26

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