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    Rpi Ribose-5-phosphate isomerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246599, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rpiprovided by FlyBase
    Official Full Name
    Ribose-5-phosphate isomeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050410
    Locus tag
    Dmel_CG30410
    See related
    AllianceGenome:FB:FBgn0050410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30410; CG9872; Dmel\CG30410; rpi
    Summary
    Enables ribose-5-phosphate isomerase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpi in Genome Data Viewer
    Location:
    59D8-59D8; 2-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23355183..23356441)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19242706..19243964)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pentose shunt in wild-type and glucose-6-phosphate dehydrogenase deficient Drosophila melanogaster. Geer BW, et al. J Exp Zool, 1974 Jan. PMID 4149211
    2. Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila. Wang CT, et al. Aging Cell, 2012 Feb. PMID 22040003, Free PMC Article
    3. Cellular metabolic reprogramming controls sugar appetite in Drosophila. Carvalho-Santos Z, et al. Nat Metab, 2020 Sep. PMID 32868922
    4. Glial expression of disease-associated poly-glutamine proteins impairs the blood-brain barrier in Drosophila. Yeh PA, et al. Hum Mol Genet, 2018 Jul 15. PMID 29726932
    5. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribose-5-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose-5-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose-5-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-ribose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, non-oxidative branch IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ribose-5-phosphate isomerase
    Names
    CG30410-PB
    CG30410-PC
    Rpi-PB
    Rpi-PC
    ribose-5-phosphate isomerase
    NP_001246480.1
    NP_726309.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23355183..23356441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259551.1 → NP_001246480.1  Ribose-5-phosphate isomerase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246480.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNB7, Q8MLS2
      Conserved Domains (1) summary
      cd01398
      Location:24 → 231
      RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...

    2. NM_166594.2 → NP_726309.3  Ribose-5-phosphate isomerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726309.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNB7, Q8MLS2
      Conserved Domains (1) summary
      cd01398
      Location:24 → 231
      RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLS2 Q8MLS2

    Gene LinkOut

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