U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rho-5 rhomboid-5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768944, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rho-5provided by FlyBase
    Official Full Name
    rhomboid-5provided by FlyBase
    Primary source
    FLYBASE:FBgn0041723
    Locus tag
    Dmel_CG33304
    See related
    AllianceGenome:FB:FBgn0041723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33304; CG5364; CT17046; Dmel\CG33304; iRhom; iRhom1; Rho-related[31D10]
    Summary
    Involved in negative regulation of epidermal growth factor receptor signaling pathway and positive regulation of circadian sleep/wake cycle, wakefulness. Located in endoplasmic reticulum membrane. Is expressed in adult head; embryonic/larval optic lobe; eye disc posterior to the morphogenetic furrow; larval brain; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF1 (rhomboid 5 homolog 1) and RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rho-5 in Genome Data Viewer
    Location:
    31D10-31D11; 2-41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10368025..10373900, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10368025..10373900, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lowfat Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 19 Neighboring gene garnysstan Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Inactive rhomboid proteins: New mechanisms with implications in health and disease. Lemberg MK, et al. Semin Cell Dev Biol, 2016 Dec. PMID 27378062
    2. iRhoms; Its Functions and Essential Roles. Lee MY, et al. Biomol Ther (Seoul), 2016 Mar 1. PMID 26869525, Free PMC Article
    3. Rhomboids, signalling and cell biology. Freeman M. Biochem Soc Trans, 2016 Jun 15. PMID 27284064, Free PMC Article
    4. iRhom1 regulates proteasome activity via PAC1/2 under ER stress. Lee W, et al. Sci Rep, 2015 Jun 25. PMID 26109405, Free PMC Article
    5. Evolution of a distinct genomic domain in Drosophila: comparative analysis of the dot chromosome in Drosophila melanogaster and Drosophila virilis. Leung W, et al. Genetics, 2010 Aug. PMID 20479145, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, wakefulness IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rhomboid-5
    Names
    CG33304-PA
    rho-5-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10368025..10373900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205957.3 → NP_995679.1  rhomboid-5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1NZB2, Q76NQ1
      Conserved Domains (1) summary
      pfam01694
      Location:1090 → 1225
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76NQ1.1 Q76NQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools