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    hwt heavyweight [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hwtprovided by FlyBase
    Official Full Name
    heavyweightprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264542
    Locus tag
    Dmel_CG43921
    See related
    AllianceGenome:FB:FBgn0264542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    43921; BcDNA:GH02424; CG11146; CG15729; CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981
    Old locus tag
    Dmel_CG11146; Dmel_CG15729; Dmel_CG32653; Dmel_CG42251
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Orthologous to several human genes including SHB (SH2 domain containing adaptor protein B); SHE (Src homology 2 domain containing E); and SHF (Src homology 2 domain containing F). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hwt in Genome Data Viewer
    Location:
    11A12-11B1; 1-39 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12516634..12568452, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12410667..12462485, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Meckel syndrome, type 1 Neighboring gene meduse Neighboring gene Cuticular protein 11B Neighboring gene Protein interacting with Ttk69 and Sin3A Neighboring gene LIM domain kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. Nelson CS, et al. BMC Genomics, 2016 Nov 4. PMID 27809764, Free PMC Article
    2. The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes. Weake VM, et al. BMC Mol Biol, 2007 May 19. PMID 17511883, Free PMC Article
    3. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article
    4. EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin. Golovnin A, et al. PLoS One, 2015. PMID 26489095, Free PMC Article
    5. Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Hoi CS, et al. Genetics, 2016 Jul. PMID 27194748, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heavyweight
    Names
    CG43921-PA
    CG43921-PB
    CG43921-PC
    CG43921-PD
    hwt-PA
    hwt-PB
    hwt-PC
    hwt-PD
    NP_001285156.1
    • non-AUG (AUC) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12516634..12568452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272555.2 → NP_001259484.1  heavyweight, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259484.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEE4
      Conserved Domains (1) summary
      cd09945
      Location:1666 → 1763
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)

    2. NM_132578.3 → NP_572806.2  heavyweight, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572806.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYM1
      Conserved Domains (1) summary
      cd09945
      Location:778 → 875
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)

    3. NM_167324.3 → NP_727617.2  heavyweight, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727617.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV33
      Conserved Domains (2) summary
      cd09945
      Location:1408 → 1505
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)
      cl22851
      Location:2 → 61
      PHD_SF; PHD finger superfamily

    4. NM_001298227.1 → NP_001285156.1  heavyweight, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDE5
      Conserved Domains (1) summary
      cd09945
      Location:1347 → 1444
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEE4 M9PEE4
    Q7KV33 Q7KV33
    Q95TC4 Q95TC4
    Q9VYM1 Q9VYM1
    X2JDE5 X2JDE5

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