Fer3HCH Ferritin 3 heavy chain homologue [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fer3HCHprovided by FlyBase
Official Full Name: Ferritin 3 heavy chain homologueprovided by FlyBase
Primary source: FLYBASE:FBgn0030449
Locus tag: Dmel_CG4349
See related: AllianceGenome:FB:FBgn0030449
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4349; Dmel\CG4349; Fer3; Fer3 HCH; FtMt
Summary: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Involved in cellular response to iron ion starvation. Predicted to be active in cytoplasm. Is expressed in several structures, including adult Malpighian tubule; adult gut; anterior-posterior subdivision of organism; spermatozoon; and testis. Used to study candidiasis. Human ortholog(s) of this gene implicated in basal ganglia disease; hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegenerative disease (multiple). Orthologous to several human genes including FTHL17 (ferritin heavy chain like 17) and FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13107382..13108194, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13001415..13002227, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferroxidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed

NP_572854.1

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The following sections contain reference sequences that belong to a specific genome build. Explain