Ppox Protoporphyrinogen oxidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ppoxprovided by FlyBase
Official Full Name: Protoporphyrinogen oxidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0020018
Locus tag: Dmel_CG5796
See related: AllianceGenome:FB:FBgn0020018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD41392; CG5796; Dmel\CG5796; ESTS:9F2T; PPO
Summary: Predicted to enable oxygen-dependent protoporphyrinogen oxidase activity. Predicted to be involved in heme biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; adult heart; and organism. Used to study porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24660197..24661851, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20485919..20487573, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables oxygen-dependent protoporphyrinogen oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen-dependent protoporphyrinogen oxidase activity	IEA Inferred from Electronic Annotation more info
enables oxygen-dependent protoporphyrinogen oxidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info

NP_651278.2

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The following sections contain reference sequences that belong to a specific genome build. Explain