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    ebd1 earthbound 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ebd1provided by FlyBase
    Official Full Name
    earthbound 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035153
    Locus tag
    Dmel_CG3371
    See related
    AllianceGenome:FB:FBgn0035153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3371; Dmel\CG3371; Ebd; Ebd1; EP3592
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in adult somatic muscle development; positive regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; mesoderm; salivary gland; and somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ebd1 in Genome Data Viewer
    Location:
    61C8-61C8; 3-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (682885..685549, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (682885..685549, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene highroad Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation. Huang J, et al. EMBO Rep, 2021 Apr 7. PMID 33565211, Free PMC Article
    2. A fly's eye view of quiescent neural stem cells. Gujar MR, et al. Oxf Open Neurosci, 2022. PMID 38596705, Free PMC Article
    3. Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective. Tian A, et al. J Dev Biol, 2018 Mar 28. PMID 29615557, Free PMC Article
    4. Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. Xin N, et al. Development, 2011 Nov. PMID 22028028, Free PMC Article
    5. High-resolution in situ hybridization analysis on the chromosomal interval 61C7-61C8 of Drosophila melanogaster reveals interbands as open chromatin domains. Zielke T, et al. Chromosoma, 2016 Jun. PMID 26520107

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    earthbound 1
    Names
    CG3371-PA
    earthbound
    ebd1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      682885..685549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138206.2 → NP_612050.1  earthbound 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0N9
      Related
      FBpp0072506
      Conserved Domains (2) summary
      smart00674
      Location:158 → 224
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      cl21459
      Location:90 → 138
      HTH; Helix-turn-helix domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0N9 Q9W0N9

    Gene LinkOut

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