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    Lmpt Limpet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39889, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lmptprovided by FlyBase
    Official Full Name
    Limpetprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261565
    Locus tag
    Dmel_CG42679
    See related
    AllianceGenome:FB:FBgn0261565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE37250; CG11914; CG11915; CG11916; CG32171; CG33256; CG42679; CG9959; Dmel\CG42679; lmpt
    Old locus tag
    Dmel_CG11915; Dmel_CG32171; Dmel_CG33256
    Summary
    Predicted to enable zinc ion binding activity. Involved in defense response to fungus and negative regulation of canonical Wnt signaling pathway. Located in I band. Is expressed in several structures, including adult head; epithelium; gut section; larval muscle cell; and trunk visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lmpt in Genome Data Viewer
    Location:
    73D3-73D6; 3-45 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16865295..16922487)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16858395..16915587)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rhodopsin 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45898 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nutritional conditional lethal mutant due to pyridoxine 5'-phosphate oxidase deficiency in Drosophila melanogaster. Chi W, et al. G3 (Bethesda), 2014 Apr 16. PMID 24739647, Free PMC Article
    2. The function of Lmpt in Drosophila heart tissue. She M, et al. Biochem Biophys Res Commun, 2022 Jul 5. PMID 35500437
    3. Whole-genome expression profiles identify gene batteries in Drosophila. Stathopoulos A, et al. Dev Cell, 2002 Oct. PMID 12408796
    4. The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis. Maier D. Hereditas, 2019. PMID 30679936, Free PMC Article
    5. Lmpt regulates the function of Drosophila muscle by acting as a repressor of Wnt signaling. Zhang J, et al. Gene, 2023 Aug 5. PMID 37245676

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lmpt regulates the function of Drosophila muscle by acting as a repressor of Wnt signaling.
      Title: Lmpt regulates the function of Drosophila muscle by acting as a repressor of Wnt signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in I band HDA PubMed 
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    limpet
    Names
    CG42679-PA
    CG42679-PB
    CG42679-PC
    CG42679-PD
    CG42679-PE
    CG42679-PF
    CG42679-PG
    CG42679-PH
    CG42679-PI
    CG42679-PJ
    CG42679-PK
    CG42679-PL
    CG42679-PM
    CG42679-PO
    CG42679-PP
    Lmpt-PA
    Lmpt-PB
    Lmpt-PC
    Lmpt-PD
    Lmpt-PE
    Lmpt-PF
    Lmpt-PG
    Lmpt-PH
    Lmpt-PI
    Lmpt-PJ
    Lmpt-PK
    Lmpt-PL
    Lmpt-PM
    Lmpt-PO
    Lmpt-PP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16865295..16922487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140673.5 → NP_648930.1  limpet, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PU4, Q9VVB5
      Related
      FBpp0291921
      Conserved Domains (7) summary
      cd09414
      Location:193 → 250
      LIM1_LIMPETin; The first LIM domain of protein LIMPETin
      cd09417
      Location:256 → 311
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:314 → 372
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:379 → 432
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:440 → 491
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:499 → 554
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cd09830
      Location:100 → 183
      PET_LIMPETin_LIM-9; The PET domain of protein LIMPETin and LIM-9

    2. NM_001259879.2 → NP_001246808.1  limpet, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PU4, Q9VVB5
      Conserved Domains (7) summary
      cd09414
      Location:193 → 250
      LIM1_LIMPETin; The first LIM domain of protein LIMPETin
      cd09417
      Location:256 → 311
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:314 → 372
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:379 → 432
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:440 → 491
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:499 → 554
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cd09830
      Location:100 → 183
      PET_LIMPETin_LIM-9; The PET domain of protein LIMPETin and LIM-9

    3. NM_206388.3 → NP_996110.1  limpet, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996110.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PU4, Q9VVB5
      Conserved Domains (7) summary
      cd09414
      Location:193 → 250
      LIM1_LIMPETin; The first LIM domain of protein LIMPETin
      cd09417
      Location:256 → 311
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:314 → 372
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:379 → 432
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:440 → 491
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:499 → 554
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cd09830
      Location:100 → 183
      PET_LIMPETin_LIM-9; The PET domain of protein LIMPETin and LIM-9

    4. NM_001275047.1 → NP_001261976.2  limpet, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFX9
      Conserved Domains (7) summary
      cd09414
      Location:193 → 250
      LIM1_LIMPETin; The first LIM domain of protein LIMPETin
      cd09417
      Location:256 → 311
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:314 → 372
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:379 → 432
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:440 → 491
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:499 → 554
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cd09830
      Location:100 → 183
      PET_LIMPETin_LIM-9; The PET domain of protein LIMPETin and LIM-9

    5. NM_206387.3 → NP_996109.1  limpet, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQQ3
      Conserved Domains (7) summary
      cd09414
      Location:192 → 249
      LIM1_LIMPETin; The first LIM domain of protein LIMPETin
      cd09417
      Location:255 → 310
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:313 → 371
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:378 → 431
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:439 → 490
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:498 → 553
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cd09830
      Location:99 → 182
      PET_LIMPETin_LIM-9; The PET domain of protein LIMPETin and LIM-9

    6. NM_170635.3 → NP_730212.1  limpet, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQQ3
      Related
      FBpp0291922
      Conserved Domains (7) summary
      cd09414
      Location:192 → 249
      LIM1_LIMPETin; The first LIM domain of protein LIMPETin
      cd09417
      Location:255 → 310
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:313 → 371
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:378 → 431
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:439 → 490
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:498 → 553
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cd09830
      Location:99 → 182
      PET_LIMPETin_LIM-9; The PET domain of protein LIMPETin and LIM-9

    7. NM_001202193.2 → NP_001189122.1  limpet, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRX0
      Conserved Domains (7) summary
      cd09417
      Location:694 → 741
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:744 → 802
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:809 → 862
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:870 → 921
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:929 → 984
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      pfam15346
      Location:110 → 255
      ARGLU; Arginine and glutamate-rich 1
      cl21478
      Location:100 → 181
      ATP-synt_B; ATP synthase B/B' CF(0)

    8. NM_206391.3 → NP_996113.2  limpet, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996113.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUQ6
      Conserved Domains (3) summary
      pfam15346
      Location:110 → 255
      ARGLU; Arginine and glutamate-rich 1
      cd16269
      Location:170 → 181
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:103 → 201
      GBP_C; Guanylate-binding protein, C-terminal domain

    9. NM_140674.4 → NP_648931.1  limpet, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SL1, Q9VVB6
      Conserved Domains (1) summary
      cl20817
      Location:124 → 199
      GBP_C; Guanylate-binding protein, C-terminal domain

    10. NM_206389.3 → NP_996111.1  limpet, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUQ5, Q8MYZ5
      Conserved Domains (5) summary
      cd09421
      Location:41 → 99
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:106 → 159
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:167 → 218
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:226 → 281
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cl02475
      Location:1 → 38
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    11. NM_168694.3 → NP_730213.1  limpet, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYZ5, Q9VVB7
      Related
      FBpp0291923
      Conserved Domains (5) summary
      cd09417
      Location:36 → 91
      LIM2_LIMPETin_like; The second LIM domain of protein LIMPETin and related proteins
      cd09421
      Location:94 → 152
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:159 → 212
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:220 → 271
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:279 → 334
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin

    12. NM_001316485.1 → NP_001303414.1  limpet, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUQ5, Q8MYZ5
      Conserved Domains (5) summary
      cd09421
      Location:41 → 99
      LIM3_LIMPETin; The third LIM domain of protein LIMPETin
      cd09425
      Location:106 → 159
      LIM4_LIMPETin; The fourth LIM domain of protein LIMPETin
      cd09430
      Location:167 → 218
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:226 → 281
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cl02475
      Location:1 → 38
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    13. NM_206390.2 → NP_996112.1  limpet, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVB8
      Conserved Domains (3) summary
      cd09430
      Location:126 → 177
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:185 → 240
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cl02475
      Location:73 → 118
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    14. NM_001169985.1 → NP_001163456.1  limpet, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVB8
      Conserved Domains (3) summary
      cd09430
      Location:126 → 177
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:185 → 240
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cl02475
      Location:73 → 118
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    15. NM_140676.4 → NP_648933.3  limpet, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648933.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVB8
      Related
      FBpp0291916
      Conserved Domains (3) summary
      cd09430
      Location:126 → 177
      LIM5_LIMPETin; The fifth LIM domain of protein LIMPETin
      cd09432
      Location:185 → 240
      LIM6_LIMPETin; The sixth LIM domain of protein LIMPETin
      cl02475
      Location:73 → 118
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRX0 M9MRX0
    M9PFX9 M9PFX9
    Q7KUQ5 Q7KUQ5
    Q7KUQ6 Q7KUQ6
    Q8IQQ3 Q8IQQ3
    Q8MYZ5 Q8MYZ5
    Q9VVB5 Q9VVB5
    Q9VVB6 Q9VVB6
    Q9VVB7 Q9VVB7
    Q9VVB8 Q9VVB8

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