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    CG15537 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43614, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG15537provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039770
    Locus tag
    Dmel_CG15537
    See related
    AllianceGenome:FB:FBgn0039770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    crhbp; Dmel\CG15537
    Summary
    Predicted to enable corticotropin-releasing hormone binding activity. Predicted to be involved in hormone metabolic process; hormone-mediated signaling pathway; and negative regulation of corticotropin secretion. Predicted to be active in extracellular space. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15537 in Genome Data Viewer
    Location:
    99F4-99F4; 3-100 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30435177..30443599, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26260899..26269321, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Osiris 23 Neighboring gene aralar1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons. Jetti SK, et al. Neuron, 2023 Nov 15. PMID 37611584
    2. Lef1-dependent hypothalamic neurogenesis inhibits anxiety. Xie Y, et al. PLoS Biol, 2017 Aug. PMID 28837622, Free PMC Article
    3. Transcriptional Programs of Circuit Assembly in the Drosophila Visual System. Kurmangaliyev YZ, et al. Neuron, 2020 Dec 23. PMID 33125872
    4. A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages. Corrales M, et al. Neural Dev, 2022 Aug 24. PMID 36002881, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables corticotropin-releasing hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corticotropin-releasing hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in hormone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of corticotropin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15537-PB
    CG15537-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30435177..30443599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300685.1 → NP_001287614.1  uncharacterized protein Dmel_CG15537, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVJ0, Q9VA76
      Conserved Domains (1) summary
      pfam05428
      Location:109 → 345
      CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)

    2. NM_001104511.2 → NP_001097981.1  uncharacterized protein Dmel_CG15537, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVJ0, Q9VA76
      Conserved Domains (1) summary
      pfam05428
      Location:109 → 345
      CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA76 Q9VA76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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