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    CG12020 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38233, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG12020provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035273
    Locus tag
    Dmel_CG12020
    See related
    AllianceGenome:FB:FBgn0035273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12020
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Is expressed in eye and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12020 in Genome Data Viewer
    Location:
    62B4-62B4; 3-1.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1797305..1798610)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1797305..1798610)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene alpha Spectrin Neighboring gene discs lost Neighboring gene antisense RNA:CR45818 Neighboring gene Cell division cycle 37 Neighboring gene patj Neighboring gene uncharacterized protein Neighboring gene JTBR Neighboring gene antisense RNA:CR45686

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Richard M, et al. Dev Dyn, 2006 Apr. PMID 16245332
    2. The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj. Pielage J, et al. Dev Cell, 2003 Dec. PMID 14667407
    3. Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells. Nam SC, et al. Dev Dyn, 2006 Jun. PMID 16518799
    4. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
    5. A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. Xu H, et al. EMBO J, 2004 Feb 25. PMID 14963491, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12020-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1797305..1798610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139405.1 → NP_647662.1  uncharacterized protein Dmel_CG12020 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RIE0, Q9W083
      Related
      FBpp0072661, FBtr0072778
      Conserved Domains (3) summary
      cd10747
      Location:156 → 335
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:7 → 352
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:7 → 87
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W083 Q9W083

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