mael maelstrom [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: maelprovided by FlyBase
Official Full Name: maelstromprovided by FlyBase
Primary source: FLYBASE:FBgn0016034
Locus tag: Dmel_CG11254
See related: AllianceGenome:FB:FBgn0016034
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11254; Dmel\CG11254; mae1; Mael; MAEL
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including dorsal appendage formation; negative regulation of macromolecule biosynthetic process; and oocyte differentiation. Located in P granule; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including fat body/gonad primordium; germarium; germline cell; head mesoderm; and larval central nervous system. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80A1-80A1; 3-47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22721203..22726234)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22717333..22719334)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By repressing canonical transcription of individual transposon mRNAs, Mael helps Rhi drive non-canonical transcription of piRNA precursors without generating mRNAs encoding transposon proteins.
Title: Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster.
Polo-mediated phosphorylation of Maelstrom may be a mechanism that controls oocyte determination by inactivating the pachytene checkpoint via the repression of Sir2 in Drosophila ovaries.
Title: Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila.
Study shows that the HMG protein Maelstrom is essential for Piwi-mediated silencing in Drosophila.
Title: Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression.
Mael serves as a platform that nucleates other microtubule-organizing center components to form a functional MTOC in early oocyte development
Title: Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC.
Mael ensures proper differentiation in the germline stem cell lineage by repressing miR-7
Title: Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7.
characterized a null allele of maelstrom (mael) and showed that
Title: Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 22723159-22723571 mobile_element_type = transposon:297{}2656

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in male meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule organizing center organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte nucleus localization involved in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of miRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: maelstrom

Names: CG11254-PA; CG11254-PB; CG11254-PC; CG11254-PD; mael-PA; mael-PB; mael-PC; mael-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

22721203..22726234

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001316461.1 → NP_001303390.1 maelstrom, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

O17317, Q86BG5, Q9VNS0

UniProtKB/TrEMBL

A0A0S0WNT6, L0CR46

Conserved Domains (1) summary

pfam13017
Location:123 → 336

Maelstrom; piRNA pathway germ-plasm component
NM_176388.3 → NP_788566.1 maelstrom, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788566.1

Status: REVIEWED

UniProtKB/TrEMBL

L0CR46

Related

FBpp0088574

Conserved Domains (1) summary

pfam13017
Location:126 → 339

Maelstrom; piRNA pathway germ-plasm component
NM_168958.3 → NP_730739.1 maelstrom, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730739.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17317, Q86BG5, Q9VNS0

UniProtKB/TrEMBL

A0A0S0WNT6, L0CR46

Related

FBpp0088575

Conserved Domains (1) summary

pfam13017
Location:123 → 336

Maelstrom; piRNA pathway germ-plasm component
NM_079493.4 → NP_524217.1 maelstrom, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524217.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17317, Q86BG5, Q9VNS0

UniProtKB/TrEMBL

A0A0S0WNT6, L0CR46

Related

FBpp0088576

Conserved Domains (1) summary

pfam13017
Location:123 → 336

Maelstrom; piRNA pathway germ-plasm component