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    l(2)09851 lethal (2) 09851 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46662, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)09851provided by FlyBase
    Official Full Name
    lethal (2) 09851provided by FlyBase
    Primary source
    FLYBASE:FBgn0022288
    Locus tag
    Dmel_CG12792
    See related
    AllianceGenome:FB:FBgn0022288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12792; Dmel\CG12792; GRWD1; I(2)09851; l(2)k08138
    Summary
    Predicted to be involved in ribosome biogenesis. Predicted to be active in nucleolus. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval somatic muscle cell; mesoderm; and visceral mesoderm derivative. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)09851 in Genome Data Viewer
    Location:
    41F9-41F9; 2-55 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5754517..5756327)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1642022..1643832)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene vulcan Neighboring gene apterous Neighboring gene small Cajal body-specific RNA : PsiU2-35.45 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glycoprotein 210 kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster Mutants apblot and apXasta Affect an Essential apterous Wing Enhancer. Bieli D, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840432, Free PMC Article
    2. Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development. Zhou J, et al. PLoS Genet, 2019 Sep. PMID 31553718, Free PMC Article
    3. Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules. Bieli D, et al. PLoS Genet, 2015 Oct. PMID 26468882, Free PMC Article
    4. Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. Gonsalves SE, et al. BMC Genomics, 2011 Sep 29. PMID 21958154, Free PMC Article
    5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Higa LA, et al. Nat Cell Biol, 2006 Nov. PMID 17041588

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 09851
    Names
    CG12792-PA
    CG12792-PB
    l(2)09851-PA
    l(2)09851-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5754517..5756327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273784.1 → NP_001260713.1  lethal (2) 09851, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYL1, Q9V9H6
      Conserved Domains (4) summary
      COG2319
      Location:172 → 447
      WD40; WD40 repeat [General function prediction only]
      pfam12265
      Location:53 → 120
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      sd00039
      Location:226 → 267
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:152 → 395
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_136338.3 → NP_610182.3  lethal (2) 09851, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610182.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYL1, Q9V9H6
      Related
      FBpp0085379
      Conserved Domains (4) summary
      COG2319
      Location:172 → 447
      WD40; WD40 repeat [General function prediction only]
      pfam12265
      Location:53 → 120
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      sd00039
      Location:226 → 267
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:152 → 395
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYL1 Q8SYL1

    Gene LinkOut

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