Kif5c kinesin family member 5C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif5cprovided by MGI
Official Full Name: kinesin family member 5Cprovided by MGI
Primary source: MGI:MGI:1098269
See related: Ensembl:ENSMUSG00000026764 AllianceGenome:MGI:1098269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Khc; KINN; NKHC; NKHC2
Summary: Predicted to enable several functions, including ATP hydrolysis activity; apolipoprotein receptor binding activity; and plus-end-directed microtubule motor activity. Involved in anterograde dendritic transport of messenger ribonucleoprotein complex and mRNA transport. Acts upstream of or within motor neuron axon guidance. Located in several cellular components, including axonal growth cone; ciliary rootlet; and neuronal cell body. Is expressed in several structures, including genitourinary system; nervous system; nose; and retina. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 81.9), cerebellum adult (RPKM 60.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 28.68 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (49509298..49664790)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (49619286..49774778)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF5C deficiency causes abnormal cortical neuronal migration, dendritic branching, and spine morphology in mice.
Title: KIF5C deficiency causes abnormal cortical neuronal migration, dendritic branching, and spine morphology in mice.
Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation.
Title: Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation.
Deletion of Kif5c Does Not Alter Prion Disease Tempo or Spread in Mouse Brain.
Title: Deletion of Kif5c Does Not Alter Prion Disease Tempo or Spread in Mouse Brain.
Molecular dynamics simulations show that besides the changes of the nucleotide state of the kinesin head, the large conformational changes of microtubule-tubulin induced by the strong interaction with the head are also indispensable to regulate the binding affinity of the head to microtubule.
Title: Investigating role of conformational changes of microtubule in regulating its binding affinity to kinesin by all-atom molecular dynamics simulation.
The authors concluded that kinesin-1 proteins KIF5A, -5B, and -5C are important in the anterograde transport of the majority of herpes simplex virus enveloped virions in neuronal axons and kinesin-3 proteins are less important.
Title: Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.
The molecular mechanism of the preferential binding of KIF5C to GTP-state microtubules.
Title: X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding.
syd activates KIF5C for transport and enhances its motility, increasing both its velocity and run length.
Title: Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility.
data suggest that the abundance of GTP-tubulin in axonal microtubules may underlie selective KIF5 localization and polarized axonal vesicular transport
Title: Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport.
binding of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
Title: Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables apolipoprotein receptor binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein receptor binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IEA Inferred from Electronic Annotation more info
involved_in intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary rootlet	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in distal axon	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of kinesin complex	TAS Traceable Author Statement more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin heavy chain isoform 5C

Names: kinesin heavy chain member 5C; kinesin heavy chain neuron-specific 2; kinesin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008449.3 → NP_032475.2 kinesin heavy chain isoform 5C

See identical proteins and their annotated locations for NP_032475.2

Status: VALIDATED

Source sequence(s)

BC067051, CJ113909

Consensus CDS

CCDS16024.1

UniProtKB/Swiss-Prot

P28738, Q6NXI9, Q9Z2F8

UniProtKB/TrEMBL

Q3TY51

Related

ENSMUSP00000028102.8, ENSMUST00000028102.14

Conserved Domains (4) summary

smart00129
Location:8 → 334

KISc; Kinesin motor, catalytic domain. ATPase

cd01369
Location:6 → 327

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

pfam15619
Location:605 → 798

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

cl12013
Location:636 → 817

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature