VIP1 inositol polyphosphate kinase VIP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VIP1
Official Full Name: inositol polyphosphate kinase VIP1
Primary source: SGD:S000004402
Locus tag: YLR410W
See related: AllianceGenome:SGD:S000004402; FungiDB:YLR410W; VEuPathDB:YLR410W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables inositol diphosphate pentakisphosphate diphosphatase activity and inositol phosphate kinase activity. Involved in inositol phosphate biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to several human genes including PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See VIP1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (937541..940981)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Title: Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase activities; the functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6
Title: A conserved family of enzymes that phosphorylate inositol hexakisphosphate.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diphosphoinositol pentakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol pentakisphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphoinositol pentakisphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 1-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol hexakisphosphate 1-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol hexakisphosphate 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol hexakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 6-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol polyphosphate kinase VIP1

NP_013514.1

EC 2.7.4.24

Bifunctional inositol pyrophosphate kinase and phosphatase; contains an N-terminal PP-InsP kinase domain that phosphorylates inositol hexakisphosphate and heptakisphosphate, and a C-terminal phosphatase domain that hydrolyzes both 1PP-InsP5 and 5PP-InsP5; IP7 levels decrease during starvation, suggesting a role for PP-InsP enzymes in Pi homeostasis; may regulate the dimorphic switch and the function of the cortical actin cytoskeleton

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

937541..940981

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182298.1 → NP_013514.1 TPA: inositol polyphosphate kinase VIP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013514.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ44, Q06685

UniProtKB/TrEMBL

A7A1T3, B3RHS1, N1P7D4

Conserved Domains (4) summary

pfam00328
Location:538 → 1047

His_Phos_2; Histidine phosphatase superfamily (branch 2)

pfam18086
Location:189 → 277

PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

cl17255
Location:395 → 489

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

cl40259
Location:274 → 324

Rimk_N; RimK PreATP-grasp domain