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    Gmnc geminin coiled-coil domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498102, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gmncprovided by RGD
    Official Full Name
    geminin coiled-coil domain containingprovided by RGD
    Primary source
    RGD:1563170
    See related
    EnsemblRapid:ENSRNOG00000038505 AllianceGenome:RGD:1563170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563170
    Summary
    Predicted to be involved in DNA replication; negative regulation of cell cycle; and regulation of DNA-templated DNA replication initiation. Predicted to act upstream of or within cilium assembly. Predicted to be active in nucleus. Orthologous to human GMNC (geminin coiled-coil domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 3.9), Brain (RPKM 3.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmnc in Genome Data Viewer
    Location:
    11q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (87339617..87352149)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (73836255..73847698)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (77237033..77247723)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene osteocrin Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 11 Neighboring gene uncharacterized LOC134481020 Neighboring gene uncharacterized LOC120095686 Neighboring gene interleukin 1 receptor accessory protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. Balestrini A, et al. Nat Cell Biol, 2010 May. PMID 20383140, Free PMC Article
    2. GemC1 controls multiciliogenesis in the airway epithelium. Arbi M, et al. EMBO Rep, 2016 Mar. PMID 26882546, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    geminin coiled-coil domain containing; geminin coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432508.1 → NP_001419437.1  geminin coiled-coil domain containing

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6G7A5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      87339617..87352149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248531.5 → XP_006248593.1  geminin coiled-coil domain-containing protein 1 isoform X1

      Related
      ENSRNOP00000080915.1, ENSRNOT00000120173.2
      Conserved Domains (1) summary
      pfam09457
      Location:89 → 130
      RBD-FIP; FIP domain

    2. XM_039088948.2 → XP_038944876.1  geminin coiled-coil domain-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials