LAP3 bleomycin hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: LAP3
Official Full Name: bleomycin hydrolase
Primary source: SGD:S000005183
Locus tag: YNL239W
See related: AllianceGenome:SGD:S000005183; FungiDB:YNL239W; VEuPathDB:YNL239W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BLH1; GAL6; YCP1
Summary: Enables cysteine-type peptidase activity and nucleic acid binding activity. Involved in homocysteine catabolic process; negative regulation of transcription by RNA polymerase II; and response to antibiotic. Located in cytoplasm. Orthologous to human BLMH (bleomycin hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Lap3 is spatially associated with Ape1 and selectively transported to the vacuole during nitrogen starvation.
Title: Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae.
GAL6 has a role in ethanol tolerance.
Title: Disruption of URA7 and GAL6 improves the ethanol tolerance and fermentation capacity of Saccharomyces cerevisiae.
mutagenesis and crystallographic study; structures revealed the importance of a tightly bound water molecule which stabilizes a loop near the active site and which is conserved throughout the papain family
Title: Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in homocysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in homocysteine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in homocysteine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014160.2

Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; cytosolic protein, selectively transported to vacuole during nitrogen starvation; targeted to vacuole via CVT pathway; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain