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    LDB19 Ldb19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LDB19
    Official Full Name
    Ldb19p
    Primary source
    SGD:S000005849
    Locus tag
    YOR322C
    See related
    AllianceGenome:SGD:S000005849; FungiDB:YOR322C; VEuPathDB:YOR322C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ART1
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cellular response to amino acid stimulus; positive regulation of receptor internalization; and ubiquitin-dependent endocytosis. Located in Golgi trans cisterna; cytosol; and plasma membrane. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LDB19 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (918606..921062, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene glucose N-acetyltransferase Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 Neighboring gene glutamate-5-semialdehyde dehydrogenase Neighboring gene Frt1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of a role for S. cerevisiae α-arrestin Art1 (Ldb19) in mating projection and zygote formations. Choudhary P, et al. Cell Biol Int, 2016 Jan. PMID 26314564
    2. A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides. Corbacho I, et al. Fungal Genet Biol, 2005 Sep. PMID 15993632
    3. Hypo-osmotic-like stress underlies general cellular defects of aneuploidy. Tsai HJ, et al. Nature, 2019 Jun. PMID 31068692, Free PMC Article
    4. A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast. Tumolo JM, et al. PLoS Genet, 2020 Mar. PMID 32191698, Free PMC Article
    5. TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. MacGurn JA, et al. Cell, 2011 Nov 23. PMID 22118465

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings implicate Art1 in selective regulation of mating events downstream of receptor internalization and cell cycle arrest, leading to schmoo, and ultimately zygote formation.
      Title: Evidence of a role for S. cerevisiae α-arrestin Art1 (Ldb19) in mating projection and zygote formations.
    2. Evidence prove that Ldb19 and Rod1 recruit Rsp5 to Ste2 for its internalization.
      Title: Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor internalization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ldb19p
    NP_014967.3
    • Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      918606..921062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183742.3 → NP_014967.3  TPA: Ldb19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014967.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W320, Q12502
      UniProtKB/TrEMBL
      A6ZPF5, B3LJY4, C7GNU1, C8ZH73, G2WNI7, N1NX08
      Conserved Domains (1) summary
      pfam13002
      Location:144 → 346
      LDB19; Arrestin_N terminal like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12502.1

    Gene LinkOut

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