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    NADK NAD kinase [ Homo sapiens (human) ]

    Gene ID: 65220, updated on 3-Dec-2024

    Summary

    Official Symbol
    NADKprovided by HGNC
    Official Full Name
    NAD kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:29831
    See related
    Ensembl:ENSG00000008130 MIM:611616; AllianceGenome:HGNC:29831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NADK1; dJ283E3.1
    Summary
    NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 24.4), spleen (RPKM 23.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NADK in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1751232..1780514, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1185650..1214901, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1682671..1711470, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 11A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 32 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1655889-1656728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1660738-1661238 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene solute carrier family 35 member E2A (pseudogene) Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1684563-1685092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1691433-1692390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1705547-1706048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 90 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 36 Neighboring gene Sharpr-MPRA regulatory region 14484 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1721473-1721656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 39 Neighboring gene G protein subunit beta 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1757447-1758350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 41 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1782535-1783035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1783210-1784022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 44 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1798007-1798184 Neighboring gene Sharpr-MPRA regulatory region 3728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1820039-1820538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 93 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 94 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 95 Neighboring gene GNB1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC1900, FLJ13052, FLJ37724, FLJ54695, FLJ77769, FLJ78247, FLJ78307, DKFZp686L22239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+ kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD kinase
    Names
    poly(P)/ATP NAD kinase
    NP_001185922.1
    NP_001185923.1
    NP_001185924.1
    NP_001340570.1
    NP_001340571.1
    NP_075394.3
    XP_011540311.1
    XP_016857633.1
    XP_047284587.1
    XP_047284603.1
    XP_047284612.1
    XP_054194383.1
    XP_054194384.1
    XP_054194385.1
    XP_054194386.1
    XP_054194387.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198993.2NP_001185922.1  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_001185922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AL031282, BC001709, BC024219, BM842058, CN349189
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      A6NNN3, A8K296, B7Z434, F5GXR5, O95544, Q5QPS4, Q9H2P2, Q9H931
      UniProtKB/TrEMBL
      A8K6D4, A8K6R3
      Related
      ENSP00000344340.3, ENST00000341991.7
      Conserved Domains (1) summary
      cl28462
      Location:96433
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    2. NM_001198994.2NP_001185923.1  NAD kinase isoform 2

      See identical proteins and their annotated locations for NP_001185923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (2) has two additional internal segments, as compared to isoform 1.
      Source sequence(s)
      AF250320, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS55562.1
      UniProtKB/Swiss-Prot
      O95544
      Related
      ENSP00000367890.1, ENST00000378625.5
      Conserved Domains (1) summary
      cl01255
      Location:202578
      DAGK_cat; Diacylglycerol kinase catalytic domain
    3. NM_001198995.1NP_001185924.1  NAD kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three exons from the 5' end and has an alternate 5' exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK296722, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS55561.1
      UniProtKB/TrEMBL
      A0A0A0MR98, A8K6R3
      Related
      ENSP00000339727.5, ENST00000342348.9
      Conserved Domains (1) summary
      cl01255
      Location:66401
      DAGK_cat; Diacylglycerol kinase catalytic domain
    4. NM_001353641.2NP_001340570.1  NAD kinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AL031282
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      A6NNN3, A8K296, B7Z434, F5GXR5, O95544, Q5QPS4, Q9H2P2, Q9H931
      UniProtKB/TrEMBL
      A8K6D4, A8K6R3
      Conserved Domains (1) summary
      cl28462
      Location:96433
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    5. NM_001353642.2NP_001340571.1  NAD kinase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses and alternate splice site which results in the use of an alternate start codon compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL031282
      UniProtKB/TrEMBL
      A8K6D4, A8K6R3
      Conserved Domains (1) summary
      cl28462
      Location:9346
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    6. NM_023018.5NP_075394.3  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_075394.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes variant 1 isoform (1). Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AK023114, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      A6NNN3, A8K296, B7Z434, F5GXR5, O95544, Q5QPS4, Q9H2P2, Q9H931
      UniProtKB/TrEMBL
      A8K6D4, A8K6R3
      Related
      ENSP00000341679.5, ENST00000341426.9
      Conserved Domains (1) summary
      cl28462
      Location:96433
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1751232..1780514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428631.1XP_047284587.1  NAD kinase isoform X1

      UniProtKB/Swiss-Prot
      A6NNN3, A8K296, B7Z434, F5GXR5, O95544, Q5QPS4, Q9H2P2, Q9H931
      UniProtKB/TrEMBL
      A8K6D4, A8K6R3
    2. XM_011542009.3XP_011540311.1  NAD kinase isoform X2

      See identical proteins and their annotated locations for XP_011540311.1

      Conserved Domains (1) summary
      cl01255
      Location:68330
      DAGK_cat; Diacylglycerol kinase catalytic domain
    3. XM_047428656.1XP_047284612.1  NAD kinase isoform X5

      UniProtKB/TrEMBL
      A8K6R3
    4. XM_017002144.3XP_016857633.1  NAD kinase isoform X3

    5. XM_047428647.1XP_047284603.1  NAD kinase isoform X4

    RNA

    1. XR_946747.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1185650..1214901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338408.1XP_054194383.1  NAD kinase isoform X1

      UniProtKB/TrEMBL
      A8K6D4, A8K6R3
    2. XM_054338409.1XP_054194384.1  NAD kinase isoform X2

    3. XM_054338412.1XP_054194387.1  NAD kinase isoform X5

    4. XM_054338410.1XP_054194385.1  NAD kinase isoform X3

    5. XM_054338411.1XP_054194386.1  NAD kinase isoform X4

    RNA

    1. XR_008486152.1 RNA Sequence