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    Fmo4 flavin containing monooxygenase 4 [ Mus musculus (house mouse) ]

    Gene ID: 226564, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fmo4provided by MGI
    Official Full Name
    flavin containing monooxygenase 4provided by MGI
    Primary source
    MGI:MGI:2429497
    See related
    Ensembl:ENSMUSG00000026692 AllianceGenome:MGI:2429497
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Ertd532e
    Summary
    Predicted to enable N,N-dimethylaniline monooxygenase activity. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic catabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 10.1), large intestine adult (RPKM 5.6) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fmo4 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162620757..162643788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162793188..162816072, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene myocilin Neighboring gene myocilin opposite strand Neighboring gene proline-rich coiled-coil 2C Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene flavin containing monooxygenase 1 Neighboring gene predicted gene, 32197

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. Veeravalli S, et al. Biochem Pharmacol, 2014 Jul 1. PMID 24792439
    2. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. Novick RM, et al. J Pharmacol Exp Ther, 2009 Jun. PMID 19307449, Free PMC Article
    3. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Veeravalli S, et al. Drug Metab Dispos, 2020 May. PMID 32156684
    4. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. Hernandez D, et al. Pharmacogenet Genomics, 2009 Apr. PMID 19262426
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).
      Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
    2. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
      Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124273, MGC124274

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within energy homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 4
    Names
    FMO 4
    dimethylaniline oxidase 4
    hepatic flavin-containing monooxygenase 4
    NP_659127.1
    XP_006496836.1
    XP_006496837.1
    XP_006496838.1
    XP_006496839.1
    XP_006496840.1
    XP_030109252.1
    XP_030109253.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144878.1 → NP_659127.1  dimethylaniline monooxygenase [N-oxide-forming] 4

      Status: PROVISIONAL

      Source sequence(s)
      AF461145
      Consensus CDS
      CCDS15423.1
      UniProtKB/Swiss-Prot
      Q8VHG0
      UniProtKB/TrEMBL
      Q3KP75
      Related
      ENSMUSP00000028014.4, ENSMUST00000028014.10
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 531
      FMO-like; Flavin-binding monooxygenase-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162620757..162643788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496776.4 → XP_006496839.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8VHG0
      UniProtKB/TrEMBL
      Q3KP75
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 531
      FMO-like; Flavin-binding monooxygenase-like

    2. XM_006496773.3 → XP_006496836.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

      UniProtKB/TrEMBL
      Q3KP75
      Conserved Domains (1) summary
      pfam00743
      Location:23 → 552
      FMO-like; Flavin-binding monooxygenase-like

    3. XM_006496777.3 → XP_006496840.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8VHG0
      UniProtKB/TrEMBL
      Q3KP75
      Related
      ENSMUSP00000107150.2, ENSMUST00000111525.8
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 531
      FMO-like; Flavin-binding monooxygenase-like

    4. XM_006496774.3 → XP_006496837.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

      UniProtKB/TrEMBL
      Q3KP75
      Conserved Domains (1) summary
      pfam00743
      Location:23 → 552
      FMO-like; Flavin-binding monooxygenase-like

    5. XM_006496775.4 → XP_006496838.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

      UniProtKB/TrEMBL
      Q3KP75
      Conserved Domains (1) summary
      pfam00743
      Location:23 → 552
      FMO-like; Flavin-binding monooxygenase-like

    6. XM_030253393.2 → XP_030109253.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X4

      Conserved Domains (1) summary
      pfam00743
      Location:2 → 163
      FMO-like; Flavin-binding monooxygenase-like

    7. XM_030253392.2 → XP_030109252.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X3

      Conserved Domains (1) summary
      pfam00743
      Location:23 → 184
      FMO-like; Flavin-binding monooxygenase-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHG0.3 GenPept UniProtKB/Swiss-Prot:Q8VHG0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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