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    NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 [ Homo sapiens (human) ]

    Gene ID: 374383, updated on 4-Jan-2025

    Summary

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    Official Symbol
    NCR3LG1provided by HGNC
    Official Full Name
    natural killer cell cytotoxicity receptor 3 ligand 1provided by HGNC
    Primary source
    HGNC:HGNC:42400
    See related
    Ensembl:ENSG00000188211 MIM:613714; AllianceGenome:HGNC:42400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7H6; B7-H6; DKFZp686O24166
    Summary
    B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
    Expression
    Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See NCR3LG1 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (17351800..17381661)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (17449460..17474942)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17373347..17398888)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3183 Neighboring gene nucleobindin 2 Neighboring gene uncharacterized LOC124902640 Neighboring gene uncharacterized LOC105376576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373285-17373886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373887-17374488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4488 Neighboring gene MPRA-validated peak1220 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr11:17397887-17398425 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:17399732-17400931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408081-17408734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408735-17409388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3186 Neighboring gene Sharpr-MPRA regulatory region 5134 Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene VISTA enhancer hs1977 Neighboring gene ATP binding cassette subfamily C member 8 Neighboring gene SDHC pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis. Chen H, et al. J Immunol Res, 2020. PMID 32322592, Free PMC Article
    2. Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma. Wu F, et al. Int J Oncol, 2016 Apr. PMID 26891663
    3. Tumor Therapeutics Work as Stress Inducers to Enhance Tumor Sensitivity to Natural Killer (NK) Cell Cytolysis by Up-regulating NKp30 Ligand B7-H6. Cao G, et al. J Biol Chem, 2015 Dec 11. PMID 26472927, Free PMC Article
    4. High expression of B7-H6 in human glioma tissues promotes tumor progression. Jiang T, et al. Oncotarget, 2017 Jun 6. PMID 28415577, Free PMC Article
    5. Characterization of B7H6, an endogenous ligand for the NK cell activating receptor NKp30, reveals the identity of two different soluble isoforms during normal human pregnancy. Gutierrez-Franco J, et al. Immunobiology, 2018 Jan. PMID 29055565

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma.
      Title: B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma.
    2. B7-H6 enhances F-actin rearrangement by targeting c-MYC activation to promote medulloblastoma migration and invasion.
      Title: B7-H6 enhances F-actin rearrangement by targeting c-MYC activation to promote medulloblastoma migration and invasion.
    3. NCR3LG1 (B7-H6) is a potential prognostic factor for bladder cancer patients.
      Title: NCR3LG1 (B7-H6) is a potential prognostic factor for bladder cancer patients.
    4. Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer.
      Title: Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer.
    5. B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma.
      Title: B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma.
    6. Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
      Title: Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
    7. Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.
      Title: Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.
    8. Dual role of B7-H6 as a novel prognostic marker in hepatocellular carcinoma.
      Title: Dual role of B7-H6 as a novel prognostic marker in hepatocellular carcinoma.
    9. Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis.
      Title: Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis.
    10. The prognostic value of B7-H6 in esophageal squamous cell carcinoma.
      Title: The prognostic value of B7-H6 in esophageal squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NCR3LG1 PubMed
    Knockdown of B7 homolog 6 (B7H6; DKFZp686O24166) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686I21167

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NK T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    natural cytotoxicity triggering receptor 3 ligand 1
    Names
    B7 homolog 6
    putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202439.3 → NP_001189368.1  natural cytotoxicity triggering receptor 3 ligand 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124798, KC877395
      Consensus CDS
      CCDS55748.1
      UniProtKB/Swiss-Prot
      Q68D85, Q7Z3M6
      Related
      ENSP00000341637.4, ENST00000338965.9
      Conserved Domains (2) summary
      pfam01140
      Location:296 → 377
      Gag_MA; Matrix protein (MA), p15
      cl11960
      Location:105 → 240
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      17351800..17381661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426906.1 → XP_047282862.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

      UniProtKB/Swiss-Prot
      Q68D85, Q7Z3M6

    2. XM_011520074.4 → XP_011518376.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X2

      Conserved Domains (3) summary
      smart00410
      Location:5 → 110
      IG_like; Immunoglobulin like
      pfam01140
      Location:267 → 348
      Gag_MA; Matrix protein (MA), p15
      cl11960
      Location:76 → 211
      Ig; Immunoglobulin domain

    3. XM_011520075.4 → XP_011518377.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X2

      Conserved Domains (3) summary
      smart00410
      Location:5 → 110
      IG_like; Immunoglobulin like
      pfam01140
      Location:267 → 348
      Gag_MA; Matrix protein (MA), p15
      cl11960
      Location:76 → 211
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      17449460..17474942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009913.1: Suppressed sequence

      Description
      NM_001009913.1: This RefSeq was permanently suppressed because it is mostly repetitive sequence.

    2. NR_026750.1: Suppressed sequence

      Description
      NR_026750.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68D85.1 GenPept UniProtKB/Swiss-Prot:Q68D85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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