Tmem87a transmembrane protein 87A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem87aprovided by MGI
Official Full Name: transmembrane protein 87Aprovided by MGI
Primary source: MGI:MGI:2441844
See related: Ensembl:ENSMUSG00000033808 AllianceGenome:MGI:2441844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A930025J12Rik
Summary: Involved in detection of mechanical stimulus involved in sensory perception of touch. Predicted to be located in plasma membrane and ruffle. Predicted to be active in Golgi cisterna membrane. Is expressed in facial ganglion. Orthologous to human TMEM87A (transmembrane protein 87A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 9.4), bladder adult (RPKM 9.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.31 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (120185790..120234597, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (120355309..120404154, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory.
Title: GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory.
Touch sensation requires the mechanically gated ion channel ELKIN1.
Title: Touch sensation requires the mechanically gated ion channel ELKIN1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB284526 (e-PCR)
- UniSTS:207388

D2Dcr27 (e-PCR), detects polymorphism
- UniSTS:142302

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi cisterna membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane protein 87A

Names: elkin1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110496.1 → NP_001103966.1 transmembrane protein 87A isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK044591, AL844608, BY149198

Consensus CDS

CCDS50677.1

UniProtKB/Swiss-Prot

Q8BTV9, Q8BU98, Q8BXN9, Q8R2P9, Q8R3S7

UniProtKB/TrEMBL

A2AQJ5

Related

ENSMUSP00000087496.6, ENSMUST00000090042.12

Conserved Domains (1) summary

pfam06814
Location:210 → 471

Lung_7-TM_R; Lung seven transmembrane receptor
NM_001110497.1 → NP_001103967.1 transmembrane protein 87A isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AK086738, AL844608, BY149198

UniProtKB/Swiss-Prot

Q8BTV9, Q8BU98, Q8BXN9, Q8R2P9, Q8R3S7

Conserved Domains (1) summary

pfam06814
Location:210 → 471

Lung_7-TM_R; Lung seven transmembrane receptor
NM_173734.3 → NP_776095.2 transmembrane protein 87A isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AK044591, AK134268, AL844608, BY149198

Consensus CDS

CCDS50678.1

UniProtKB/Swiss-Prot

Q8BTV9, Q8BU98, Q8BXN9, Q8R2P9, Q8R3S7

UniProtKB/TrEMBL

A2AQJ6

Related

ENSMUSP00000087500.6, ENSMUST00000090046.12

Conserved Domains (1) summary

pfam06814
Location:210 → 472

Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

120185790..120234597 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499077.3 → XP_006499140.1 transmembrane protein 87A isoform X1

UniProtKB/Swiss-Prot

Q8BTV9, Q8BU98, Q8BXN9, Q8R2P9, Q8R3S7

Related

ENSMUST00000136410.8

Conserved Domains (1) summary

pfam06814
Location:186 → 472

Lung_7-TM_R; Lung seven transmembrane receptor
XM_011239411.2 → XP_011237713.1 transmembrane protein 87A isoform X4

Conserved Domains (1) summary

pfam06814
Location:43 → 329

Lung_7-TM_R; Lung seven transmembrane receptor
XM_011239409.1 → XP_011237711.1 transmembrane protein 87A isoform X2

UniProtKB/Swiss-Prot

Q8BTV9, Q8BU98, Q8BXN9, Q8R2P9, Q8R3S7

Conserved Domains (1) summary

pfam06814
Location:138 → 424

Lung_7-TM_R; Lung seven transmembrane receptor
XM_011239410.3 → XP_011237712.1 transmembrane protein 87A isoform X3

UniProtKB/TrEMBL

A2AQJ7

Related

ENSMUSP00000106357.2, ENSMUST00000110729.2

Conserved Domains (1) summary

pfam06814
Location:186 → 472

Lung_7-TM_R; Lung seven transmembrane receptor
XM_011239412.4 → XP_011237714.1 transmembrane protein 87A isoform X5