Trip13 thyroid hormone receptor interactor 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trip13provided by MGI
Official Full Name: thyroid hormone receptor interactor 13provided by MGI
Primary source: MGI:MGI:1916966
See related: Ensembl:ENSMUSG00000021569 AllianceGenome:MGI:1916966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D13Ertd328e; 2410002G23Rik
Summary: Predicted to enable identical protein binding activity. Involved in several processes, including double-strand break repair; meiosis I; and spermatogenesis. Acts upstream of or within germ cell development and meiosis I. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 11.3), placenta adult (RPKM 8.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.15 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (74060577..74085855, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (73912450..73937795, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global loss of TRIP13 leads to meiotic arrest and TRIP13 is a dosage sensitive regulator of meiosis.
Title: TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.
TRIP13 localizes to the central region of the synaptonemal complex and telomeres in spermatocytes.
Title: TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
Title: Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies.
Title: TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies.
In all, these studies suggest that insufficient TRIP13 increased the susceptibility of damaged tubular epithelial cells to progress towards apoptotic cell death.
Title: TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury.
TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM.
Title: TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma.
TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2
Title: The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.
TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.
Title: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.
TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.
Title: Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis.
HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13.
Title: Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trip13 (e-PCR), detects polymorphism
- UniSTS:547384

Trip13 (e-PCR), detects polymorphism
- UniSTS:507963

Trip13 (e-PCR), detects polymorphism
- UniSTS:507964

RH126970 (e-PCR)
- UniSTS:167107

NoName (e-PCR)
- UniSTS:237054

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic recombination checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pachytene checkpoint protein 2 homolog

Names: TR-interacting protein 13; TRIP-13; thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418622.1 → NP_001405551.1 pachytene checkpoint protein 2 homolog isoform 2

Status: VALIDATED

Source sequence(s)

CT010471
NM_001418623.1 → NP_001405552.1 pachytene checkpoint protein 2 homolog isoform 3

Status: VALIDATED

Source sequence(s)

CT010471
NM_001418624.1 → NP_001405553.1 pachytene checkpoint protein 2 homolog isoform 4

Status: VALIDATED

Source sequence(s)

CT010471
NM_027182.3 → NP_081458.1 pachytene checkpoint protein 2 homolog isoform 1

See identical proteins and their annotated locations for NP_081458.1

Status: VALIDATED

Source sequence(s)

CT010471

Consensus CDS

CCDS26637.1

UniProtKB/Swiss-Prot

A0JNT8, Q05CL4, Q3UA06, Q3UQG6, Q9CWW8

Related

ENSMUSP00000022053.9, ENSMUST00000022053.11

Conserved Domains (2) summary

smart00382
Location:172 → 322

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:175 → 320

AAA; ATPase family associated with various cellular activities (AAA)