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    Mageb16 MAGE family member B16 [ Mus musculus (house mouse) ]

    Gene ID: 71967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mageb16provided by MGI
    Official Full Name
    MAGE family member B16provided by MGI
    Primary source
    MGI:MGI:1919217
    See related
    Ensembl:ENSMUSG00000046942 AllianceGenome:MGI:1919217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410003J06Rik
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; heart; liver; and reproductive system. Orthologous to human MAGEB16 (MAGE family member B16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 10.9) and testis adult (RPKM 3.3) See more
    Orthologs
    human all
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    Genomic context

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    See Mageb16 in Genome Data Viewer
    Location:
    X B; X 38.38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (78666837..78715041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (79623231..79671435, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47437 Neighboring gene cilia and flagella associated protein 47 Neighboring gene STARR-seq mESC enhancer starr_47438 Neighboring gene STARR-seq mESC enhancer starr_47439 Neighboring gene STARR-seq mESC enhancer starr_47441 Neighboring gene STARR-seq mESC enhancer starr_47442 Neighboring gene STARR-seq mESC enhancer starr_47443 Neighboring gene predicted gene, 17817 Neighboring gene STARR-seq mESC enhancer starr_47444 Neighboring gene hepatoma-derived growth factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_47445 Neighboring gene STARR-seq mESC enhancer starr_47446 Neighboring gene STARR-seq mESC enhancer starr_47447 Neighboring gene STARR-seq mESC enhancer starr_47448 Neighboring gene STARR-seq mESC enhancer starr_47449 Neighboring gene ring finger protein pseudogene Neighboring gene prohibitin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives. Gaspar JA, et al. Sci Rep, 2017 Oct 27. PMID 29079788, Free PMC Article
    2. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen B16
    Names
    MAGE-B16 antigen
    Novel MAGE family protein
    melanoma antigen family B, 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113734.1 → NP_001107206.1  melanoma-associated antigen B16

      See identical proteins and their annotated locations for NP_001107206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK010362, BY387905, CJ081836
      Consensus CDS
      CCDS53122.1
      UniProtKB/Swiss-Prot
      Q3TJP9, Q9CWV4
      Related
      ENSMUSP00000109649.4, ENSMUST00000114016.10
      Conserved Domains (1) summary
      pfam01454
      Location:217 → 303
      MAGE; MAGE family

    2. NM_028025.1 → NP_082301.1  melanoma-associated antigen B16

      See identical proteins and their annotated locations for NP_082301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AK010362, BY387905
      Consensus CDS
      CCDS53122.1
      UniProtKB/Swiss-Prot
      Q3TJP9, Q9CWV4
      Related
      ENSMUSP00000087292.4, ENSMUST00000052283.7
      Conserved Domains (1) summary
      pfam01454
      Location:217 → 303
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      78666837..78715041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247683.3 → XP_011245985.1  melanoma-associated antigen B16 isoform X1

      See identical proteins and their annotated locations for XP_011245985.1

      UniProtKB/Swiss-Prot
      Q3TJP9, Q9CWV4
      Conserved Domains (1) summary
      pfam01454
      Location:217 → 303
      MAGE; MAGE family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWV4.1 GenPept UniProtKB/Swiss-Prot:Q9CWV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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