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    Nkx2-4 NK2 homeobox 4 [ Mus musculus (house mouse) ]

    Gene ID: 228731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkx2-4provided by MGI
    Official Full Name
    NK2 homeobox 4provided by MGI
    Primary source
    MGI:MGI:97349
    See related
    Ensembl:ENSMUSG00000054160 AllianceGenome:MGI:97349
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tinman; Nkx-2.4; 1700001P03Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human NKX2-4 (NK2 homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Nkx2-4 in Genome Data Viewer
    Location:
    2 G2; 2 72.63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146925257..146927359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (147083337..147085439, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kizuna centrosomal protein Neighboring gene Mki67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_05954 Neighboring gene STARR-seq mESC enhancer starr_05956 Neighboring gene STARR-seq mESC enhancer starr_05957 Neighboring gene 5'-3' exoribonuclease 2 Neighboring gene predicted gene, 34889 Neighboring gene NK2 homeobox 2 Neighboring gene predicted gene, 57697

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Price M, et al. Neuron, 1992 Feb. PMID 1346742
    2. Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia. Yoshiura KI, et al. Genomics, 1997 Oct 15. PMID 9344671
    3. Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals. Wang CC, et al. Mamm Genome, 2000 Jun. PMID 10818213
    4. Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder. Shen T, et al. Nucleic Acids Res, 2018 Mar 16. PMID 29294103, Free PMC Article
    5. Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Marín O, et al. Development, 2002 Feb. PMID 11830575

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Nkx-2.4
    Names
    NK2 transcription factor related, locus 4
    homeobox protein NK-2 homolog D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023504.1 → NP_075993.1  homeobox protein Nkx-2.4

      See identical proteins and their annotated locations for NP_075993.1

      Status: PROVISIONAL

      Source sequence(s)
      AF202038
      Consensus CDS
      CCDS16833.1
      UniProtKB/Swiss-Prot
      A2ATK2, Q9EQM3, Q9EQM4
      Related
      ENSMUSP00000066690.3, ENSMUST00000067020.3
      Conserved Domains (1) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      146925257..146927359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499301.1 → XP_006499364.1  homeobox protein Nkx-2.4 isoform X1

      Conserved Domains (1) summary
      pfam00046
      Location:159 → 213
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQM3.2 GenPept UniProtKB/Swiss-Prot:Q9EQM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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