Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpul2provided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein U-like 2provided by MGI
Primary source: MGI:MGI:1915943
See related: Ensembl:ENSMUSG00000071659 AllianceGenome:MGI:1915943
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpul2; 1110031M08Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Located in nucleus. Is active in synapse. Is expressed in central nervous system; olfactory epithelium; retina layer; and submandibular gland primordium. Orthologous to human HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 45.1), CNS E14 (RPKM 27.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.7 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8796765..8811507)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8819401..8834143)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrnpul2 (e-PCR), detects polymorphism
- UniSTS:527388

NoName (e-PCR)
- UniSTS:237884

RH140544 (e-PCR)
- UniSTS:222613

AI465155 (e-PCR)
- UniSTS:181199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein U-like protein 2

Names: MLF1-associated nuclear protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081196.1 → NP_001074665.1 heterogeneous nuclear ribonucleoprotein U-like protein 2

See identical proteins and their annotated locations for NP_001074665.1

Status: VALIDATED

Source sequence(s)

AC129217

Consensus CDS

CCDS37908.1

UniProtKB/Swiss-Prot

F8VPM4, Q00PI9

Related

ENSMUSP00000094515.4, ENSMUST00000096753.5

Conserved Domains (4) summary

smart00513
Location:3 → 37

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam13671
Location:452 → 597

AAA_33; AAA domain

cd12884
Location:244 → 415

SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

cl17190
Location:452 → 634

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...