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    Fmo2 flavin containing monooxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 55990, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fmo2provided by MGI
    Official Full Name
    flavin containing monooxygenase 2provided by MGI
    Primary source
    MGI:MGI:1916776
    See related
    Ensembl:ENSMUSG00000040170 AllianceGenome:MGI:1916776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310008D08Rik; 2310042I22Rik
    Summary
    Enables monooxygenase activity. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and oxygen metabolic process. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; limb; mesothelium; metanephros; and nose. Orthologous to human FMO2 (flavin containing dimethylaniline monoxygenase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 71.4), lung adult (RPKM 60.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fmo2 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162701886..162726327, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162874317..162898758, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm713 Neighboring gene flavin containing monooxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene predicted gene, 32197 Neighboring gene flavin containing monooxygenase 6 Neighboring gene predicted gene, 32279 Neighboring gene flavin containing monooxygenase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. Karoly ED, et al. J Biochem Mol Toxicol, 2001. PMID 11835629
    2. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Yoshida Y, et al. Sci Rep, 2022 Sep 1. PMID 36050466, Free PMC Article
    3. The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein. Lattard V, et al. Biochem Biophys Res Commun, 2002 Mar 29. PMID 11906197
    4. The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. Veeravalli S, et al. Biochem Pharmacol, 2014 Jul 1. PMID 24792439
    5. Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation. Wang L, et al. Int J Mol Med, 2023 Nov. PMID 37800598, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD transformation.
      Title: Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation.
    2. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).
      Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
    3. sequencing, expression, and characterization of cDNA
      Title: Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28212

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within energy homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in organic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oxygen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in toxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 2
    Names
    FMO 2
    dimethylaniline oxidase 2
    pulmonary flavin-containing monooxygenase 2
    NP_001347842.1
    NP_001347843.1
    NP_061369.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360913.1 → NP_001347842.1  dimethylaniline monooxygenase [N-oxide-forming] 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC117767, AF184981
      Consensus CDS
      CCDS15425.1
      UniProtKB/Swiss-Prot
      Q8K2I3, Q9QZF7
      Related
      ENSMUSP00000107135.2, ENSMUST00000111510.8
      Conserved Domains (1) summary
      cl26174
      Location:2 → 532
      K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)

    2. NM_001360914.1 → NP_001347843.1  dimethylaniline monooxygenase [N-oxide-forming] 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC117767, AF184981, AI876829
      Consensus CDS
      CCDS15425.1
      UniProtKB/Swiss-Prot
      Q8K2I3, Q9QZF7
      Conserved Domains (1) summary
      cl26174
      Location:2 → 532
      K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)

    3. NM_018881.4 → NP_061369.2  dimethylaniline monooxygenase [N-oxide-forming] 2

      See identical proteins and their annotated locations for NP_061369.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC117767
      Consensus CDS
      CCDS15425.1
      UniProtKB/Swiss-Prot
      Q8K2I3, Q9QZF7
      Related
      ENSMUSP00000044405.7, ENSMUST00000045902.13
      Conserved Domains (1) summary
      cl26174
      Location:2 → 532
      K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162701886..162726327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2I3.3 GenPept UniProtKB/Swiss-Prot:Q8K2I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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