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    Zfp263 zinc finger protein 263 [ Mus musculus (house mouse) ]

    Gene ID: 74120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp263provided by MGI
    Official Full Name
    zinc finger protein 263provided by MGI
    Primary source
    MGI:MGI:1921370
    See related
    Ensembl:ENSMUSG00000022529 AllianceGenome:MGI:1921370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NT2; Znf263; mFPM315; 1200014J04Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF263 (zinc finger protein 263). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.6), CNS E18 (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp263 in Genome Data Viewer
    Location:
    16 A1; 16 2.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3561883..3568654)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3744099..3750790)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene teratocarcinoma-derived growth factor, pseudogene 1 Neighboring gene predicted gene, 57641 Neighboring gene STARR-positive B cell enhancer ABC_E4152 Neighboring gene predicted gene, 36195 Neighboring gene STARR-seq mESC enhancer starr_39909 Neighboring gene predicted gene, 41409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Yokoyama M, et al. Biochim Biophys Acta, 1997 Jul 17. PMID 9256059
    2. Identification of SCAN dimerization domains in four gene families. Honer C, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342224
    3. Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes. Kajioka D, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074765, Free PMC Article
    4. Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region. Ning Z, et al. Hum Mol Genet, 2015 Sep 15. PMID 26089202
    5. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 263
    Names
    kruppel-associated box-zinc finger protein NT2
    zinc finger protein FPM315
    zinc finger protein with KRAB and SCAN domains 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148924.3 → NP_683726.2  zinc finger protein 263

      See identical proteins and their annotated locations for NP_683726.2

      Status: VALIDATED

      Source sequence(s)
      AK004765, BY507217, BY718780
      Consensus CDS
      CCDS27909.1
      UniProtKB/Swiss-Prot
      E9PXW0, Q7TMI6, Q8CF60, Q8K439
      Related
      ENSMUSP00000023176.5, ENSMUST00000023176.5
      Conserved Domains (6) summary
      smart00431
      Location:41 → 151
      SCAN; leucine rich region
      cd07765
      Location:219 → 253
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:415 → 646
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:380 → 400
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:645 → 667
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3561883..3568654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522653.4 → XP_006522716.1  zinc finger protein 263 isoform X1

      Related
      ENSMUST00000159425.8
      Conserved Domains (4) summary
      COG5048
      Location:298 → 484
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:483 → 505
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:58 → 116
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CF60.1 GenPept UniProtKB/Swiss-Prot:Q8CF60

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