Bex1 brain expressed X-linked 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bex1provided by MGI
Official Full Name: brain expressed X-linked 1provided by MGI
Primary source: MGI:MGI:1328321
See related: Ensembl:ENSMUSG00000050071 AllianceGenome:MGI:1328321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bex2; Bex4; Rex3
Summary: Enables molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within axon regeneration. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; ganglia; genitourinary system; and gut. Orthologous to human BEX1 (brain expressed X-linked 1) and BEX2 (brain expressed X-linked 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: The Bex1 and Bex2 genes appear to have undergone gene conversion, exchanging bits of coding sequence with each other. This complicates determination of orthologs in other species. For this reason, gene name assignments may not be consistent between species. [06 Dec 2023]
Expression: Biased expression in placenta adult (RPKM 230.0), liver E14 (RPKM 115.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 57.4 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (135114721..135116262, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (136213972..136215513, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARgamma/PDK1 dependent manner.
Title: BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARγ/PDK1 dependent manner.
Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity.
Title: Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity.
Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.
Title: Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.
BEX1 functions as an mRNA-dependent effector that augments pathology-promoting gene expression during heart failure.
Title: BEX1 is an RNA-dependent mediator of cardiomyopathy.
These results elucidate a novel role of Bex1 in myogenesis through regulating myoblast fusion.
Title: The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion.
Bex family members play important roles in the formation of protein network hubs.
Title: Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs.
Bex1 protein is over-expressed as a result of peripheral axonal damage and antagonizes the axon outgrowth inhibitory effect of myelin-associated glycoprotein.
Title: Bex1 is involved in the regeneration of axons after injury.
Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca(2+)/CaM may be involved in skeletal muscle regeneration.
Title: Bex1 knock out mice show altered skeletal muscle regeneration.
Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos.
Title: Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos.
Bex3 may be required in target tissues for mitochondrial function at a distinct phase of the cellular growth cycle.
Title: Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126864 (e-PCR)
- UniSTS:209752

RH136276 (e-PCR)
- UniSTS:210269

Bex1 (e-PCR), detects polymorphism
- UniSTS:256694

RH125734 (e-PCR)
- UniSTS:162492

Rex3 (e-PCR), detects polymorphism
- UniSTS:144347

RH125463 (e-PCR)
- UniSTS:162282

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein BEX1

Names: REX-3; brain expressed gene 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; protein BEX2; reduced expression 3; reduced expression protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.