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    Syt4 synaptotagmin IV [ Mus musculus (house mouse) ]

    Gene ID: 20983, updated on 9-Dec-2024

    Summary

    Official Symbol
    Syt4provided by MGI
    Official Full Name
    synaptotagmin IVprovided by MGI
    Primary source
    MGI:MGI:101759
    See related
    Ensembl:ENSMUSG00000024261 AllianceGenome:MGI:101759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SytIV
    Summary
    The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in CNS E18 (RPKM 40.3), cerebellum adult (RPKM 32.9) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Syt4 in Genome Data Viewer
    Location:
    18 B1; 18 17.75 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (31570861..31580468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (31437808..31447415, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41681 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 pseudogene Neighboring gene predicted gene, 25396 Neighboring gene STARR-seq mESC enhancer starr_44144 Neighboring gene actin, beta pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin-3 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin-3 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dense core granule cytoskeletal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dense core granule cytoskeletal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of catecholamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of catecholamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dense core granule exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of retrograde trans-synaptic signaling by neuropeptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of short-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dense core granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion-dependent exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic dense core vesicle exocytosis EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynaptic dense core vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic dense core vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in secretory granule maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secretory granule maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion with vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle fusion with vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in astrocyte projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in microvesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuronal dense core vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal dense core vesicle membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in neuronal dense core vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in somatodendritic compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009308.3NP_033334.2  synaptotagmin-4

      See identical proteins and their annotated locations for NP_033334.2

      Status: REVIEWED

      Source sequence(s)
      AK032106, CAAA01195961, CN666882
      Consensus CDS
      CCDS29109.1
      UniProtKB/Swiss-Prot
      P40749, Q3UFC1, Q8BGH3, Q8BRL6
      UniProtKB/TrEMBL
      Q571C5
      Related
      ENSMUSP00000025110.4, ENSMUST00000025110.5
      Conserved Domains (2) summary
      cd08388
      Location:153279
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:288423
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      31570861..31580468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317852.3XP_017173341.1  synaptotagmin-4 isoform X1

      Conserved Domains (2) summary
      cd08404
      Location:106241
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
      cl14603
      Location:197
      C2; C2 domain