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    Fcna ficolin A [ Mus musculus (house mouse) ]

    Gene ID: 14133, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fcnaprovided by MGI
    Official Full Name
    ficolin Aprovided by MGI
    Primary source
    MGI:MGI:1340905
    See related
    Ensembl:ENSMUSG00000026938 AllianceGenome:MGI:1340905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fcn1
    Summary
    Predicted to enable several functions, including antigen binding activity; carbohydrate derivative binding activity; and pattern recognition receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; activation of immune response; and positive regulation of interleukin-8 production. Predicted to be located in plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; embryo; liver; and spleen. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 38.4), spleen adult (RPKM 36.2) and 10 other tissues See more
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    Genomic context

    See Fcna in Genome Data Viewer
    Location:
    2 A3; 2 17.58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25514677..25525448, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25624665..25635440, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand Neighboring gene transmembrane protein 141 Neighboring gene predicted gene, 35630 Neighboring gene lipocalin 15 Neighboring gene lipocalin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate derivative binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface pattern recognition receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in complement activation, lectin pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ficolin-1
    Names
    M-ficolin
    collagen/fibrinogen domain-containing protein 1
    ficolin-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420084.1NP_001407013.1  ficolin-1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732590
      UniProtKB/TrEMBL
      Q2WFW2
    2. NM_007995.4NP_032021.1  ficolin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032021.1

      Status: VALIDATED

      Source sequence(s)
      AL732590
      Consensus CDS
      CCDS15785.1
      UniProtKB/Swiss-Prot
      O70165
      UniProtKB/TrEMBL
      Q2WFW2, Q4FJM1
      Related
      ENSMUSP00000028307.9, ENSMUST00000028307.9
      Conserved Domains (2) summary
      pfam01391
      Location:65106
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:123332
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25514677..25525448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239016.4XP_011237318.1  ficolin-1 isoform X1

      See identical proteins and their annotated locations for XP_011237318.1

      UniProtKB/Swiss-Prot
      O70165
      UniProtKB/TrEMBL
      Q2WFW2, Q4FJM1
      Conserved Domains (2) summary
      pfam01391
      Location:65106
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:123332
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. XM_006497673.5XP_006497736.1  ficolin-1 isoform X1

      See identical proteins and their annotated locations for XP_006497736.1

      UniProtKB/Swiss-Prot
      O70165
      UniProtKB/TrEMBL
      Q2WFW2, Q4FJM1
      Conserved Domains (2) summary
      pfam01391
      Location:65106
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:123332
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...