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    Qprt quinolinate phosphoribosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 67375, updated on 9-Dec-2024

    Summary

    Official Symbol
    Qprtprovided by MGI
    Official Full Name
    quinolinate phosphoribosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1914625
    See related
    Ensembl:ENSMUSG00000030674 AllianceGenome:MGI:1914625
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    QPRTase; 2410027J01Rik
    Summary
    Predicted to enable identical protein binding activity and nicotinate-nucleotide diphosphorylase (carboxylating) activity. Predicted to be involved in NAD biosynthetic process and quinolinate catabolic process. Predicted to be part of catalytic complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hindlimb; integumental system; liver; skeleton; and urinary system. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 87.0), liver E18 (RPKM 77.3) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Qprt in Genome Data Viewer
    Location:
    7 F3; 7 69.33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126706942..126721201, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127107770..127122029, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134234662-134234982 Neighboring gene expressed sequence AI467606 Neighboring gene STARR-positive B cell enhancer ABC_E6604 Neighboring gene STARR-positive B cell enhancer ABC_E9301 Neighboring gene sialophorin Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in quinolinate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within quinolinate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in quinolinate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in quinolinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of catalytic complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nicotinate-nucleotide pyrophosphorylase [carboxylating]
    Names
    QAPRTase
    nicotinate-nucleotide pyrophosphorylase
    NP_598447.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133686.1NP_598447.1  nicotinate-nucleotide pyrophosphorylase [carboxylating]

      See identical proteins and their annotated locations for NP_598447.1

      Status: PROVISIONAL

      Source sequence(s)
      BC011191
      Consensus CDS
      CCDS40138.1
      UniProtKB/Swiss-Prot
      Q91X91
      Related
      ENSMUSP00000032912.6, ENSMUST00000032912.6
      Conserved Domains (2) summary
      cd01572
      Location:17284
      QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
      TIGR00078
      Location:21285
      nadC; nicotinate-nucleotide pyrophosphorylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126706942..126721201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)