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    Lipg lipase, endothelial [ Mus musculus (house mouse) ]

    Gene ID: 16891, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lipgprovided by MGI
    Official Full Name
    lipase, endothelialprovided by MGI
    Primary source
    MGI:MGI:1341803
    See related
    Ensembl:ENSMUSG00000053846 AllianceGenome:MGI:1341803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EL; mEDL; lipase; 3110013K01Rik
    Summary
    Enables phospholipase activity. Acts upstream of or within regulation of lipoprotein metabolic process. Predicted to be located in Golgi apparatus; cell surface; and early endosome. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 41.5), ovary adult (RPKM 21.2) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Lipg in Genome Data Viewer
    Location:
    18 E2; 18 50.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75072393..75095380, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74939322..74961263, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a, pseudogene 2 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial pseudogene Neighboring gene RIKEN cDNA 9030625G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E11004 Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene ribosomal protein L17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipoprotein lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipoprotein lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables phospholipase A1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of high-density lipoprotein particle clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of high-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reverse cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endothelial lipase
    Names
    EDL
    endothelial cell-derived lipase
    lipose, endothelial
    phospholipase A1
    NP_034850.3
    XP_006525755.1
    XP_036016892.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010720.3NP_034850.3  endothelial lipase precursor

      See identical proteins and their annotated locations for NP_034850.3

      Status: VALIDATED

      Source sequence(s)
      AK014047, AK150054, AK152161, AK152430, AK152872
      Consensus CDS
      CCDS29343.1
      UniProtKB/Swiss-Prot
      Q8VDU2, Q9WVG5
      UniProtKB/TrEMBL
      C0LQ91, Q3TA44, Q3U807
      Related
      ENSMUSP00000066536.5, ENSMUST00000066532.5
      Conserved Domains (3) summary
      TIGR03230
      Location:51485
      lipo_lipase; lipoprotein lipase
      cd00707
      Location:49340
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01758
      Location:347483
      PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      75072393..75095380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160999.1XP_036016892.1  endothelial lipase isoform X2

      UniProtKB/TrEMBL
      Q3TA44, Q3U807
      Conserved Domains (1) summary
      TIGR03230
      Location:2405
      lipo_lipase; lipoprotein lipase
    2. XM_006525692.4XP_006525755.1  endothelial lipase isoform X1

      UniProtKB/TrEMBL
      Q3TA44, Q3U807
      Conserved Domains (1) summary
      TIGR03230
      Location:25416
      lipo_lipase; lipoprotein lipase