U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 21941, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tnfrsf8provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 8provided by MGI
    Primary source
    MGI:MGI:99908
    See related
    Ensembl:ENSMUSG00000028602 AllianceGenome:MGI:99908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki; Cd30; Ki-1; D1S166E
    Summary
    Predicted to enable protease binding activity. Predicted to be involved in positive regulation of TRAIL production; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor production. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including adrenal gland; brain; intestine; reproductive system; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 4.6), testis adult (RPKM 0.6) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnfrsf8 in Genome Data Viewer
    Location:
    4 E1; 4 78.17 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144993702..145041734, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (145267132..145315164, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 1b Neighboring gene STARR-positive B cell enhancer ABC_E11265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144832691-144832800 Neighboring gene STARR-positive B cell enhancer ABC_E8008 Neighboring gene predicted gene, 36233 Neighboring gene STARR-seq mESC enhancer starr_12014 Neighboring gene STARR-seq mESC enhancer starr_12016 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144885570-144885871 Neighboring gene STARR-positive B cell enhancer ABC_E1663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144909212-144909413 Neighboring gene STARR-seq mESC enhancer starr_12020 Neighboring gene STARR-positive B cell enhancer ABC_E9608 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144957328-144957437 Neighboring gene STARR-seq mESC enhancer starr_12022 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144995732-144996033 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:144997421-144997722 Neighboring gene STARR-seq mESC enhancer starr_12024 Neighboring gene predicted gene, 42346 Neighboring gene STARR-seq mESC enhancer starr_12025 Neighboring gene STARR-positive B cell enhancer ABC_E9609 Neighboring gene STARR-positive B cell enhancer ABC_E2132 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145039173-145039474 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145043961-145044261

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of TRAIL production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 8
    Names
    CD30L receptor
    lymphocyte activation antigen CD30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009401.3NP_033427.1  tumor necrosis factor receptor superfamily member 8 precursor

      See identical proteins and their annotated locations for NP_033427.1

      Status: VALIDATED

      Source sequence(s)
      AL627099
      Consensus CDS
      CCDS18915.1
      UniProtKB/Swiss-Prot
      A1L3C9, Q60846
      Related
      ENSMUSP00000030339.7, ENSMUST00000030339.13
      Conserved Domains (1) summary
      cd13409
      Location:3127
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      144993702..145041734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163966.1XP_036019859.1  tumor necrosis factor receptor superfamily member 8 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:117274
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13409
      Location:6112
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30