Cela1 chymotrypsin-like elastase family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cela1provided by MGI
Official Full Name: chymotrypsin-like elastase family, member 1provided by MGI
Primary source: MGI:MGI:95314
See related: Ensembl:ENSMUSG00000023031 AllianceGenome:MGI:95314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ela1; Ela-1; PC-TsF; 1810009A17Rik; 1810062B19Rik
Summary: Enables serine-type endopeptidase activity. Acts upstream of or within several processes, including elastin catabolic process; exocrine pancreas development; and regulation of transcription by RNA polymerase II. Located in collagen-containing extracellular matrix. Is expressed in alveolus epithelium; lung; pancreas; pancreas tip epithelium; and right lung accessory lobe. Orthologous to human CELA1 (chymotrypsin like elastase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine adult (RPKM 5257.0), spleen adult (RPKM 1973.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.38 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100572303..100585801, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100674422..100687920, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication.
Title: Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication.
Cela1 is important in physiologic and pathologic stretch-dependent remodeling processes in the postnatal lung
Title: Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema.
The stretch-dependent expression and binding kinetics of Cela1 indicate an important role in stretch-dependent remodeling of the peripheral lung during development and regeneration.
Title: Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung.
defines the temporal-spatial pattern of elastin remodeling during lung development, demonstrates an association of this remodeling with chymotrypsin-like elastase 1
Title: Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.
The enzymatic properties and kinetic profiles for mouse pancreatic elastase were similar to other known serine elastases.
Title: Enzyme kinetics and characterization of mouse pancreatic elastase.
Glucocorticoid receptor-null lungs included Chi3l3 (11-fold, P < 0.05), a macrophage inflammatory response gene and Ela1 (9.4-fold, P < 0.05), an extracellular matrix remodeling enzyme.
Title: Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within elastin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chymotrypsin-like elastase family member 1

Names: elastase 1, pancreatic; elastase-1

NP_291090.2

EC 3.4.21.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033612.2 → NP_291090.2 chymotrypsin-like elastase family member 1 precursor

See identical proteins and their annotated locations for NP_291090.2

Status: VALIDATED

Source sequence(s)

AK007392, BP769372, CB951068

Consensus CDS

CCDS37213.1

UniProtKB/Swiss-Prot

Q91X79, Q9D936, Q9Z1H1

Related

ENSMUSP00000023775.8, ENSMUST00000023775.9

Conserved Domains (2) summary

smart00020
Location:26 → 258

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:27 → 262

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...