U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tctn3 tectonic family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 67590, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tctn3provided by MGI
    Official Full Name
    tectonic family member 3provided by MGI
    Primary source
    MGI:MGI:1914840
    See related
    Ensembl:ENSMUSG00000025008 AllianceGenome:MGI:1914840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tect3; 4930521E07Rik
    Summary
    Involved in cilium assembly. Predicted to be located in nucleus. Is expressed in several structures, including brain and olfactory epithelium. Human ortholog(s) of this gene implicated in Joubert syndrome 18 and orofaciodigital syndrome IV. Orthologous to human TCTN3 (tectonic family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 7.9), testis adult (RPKM 7.3) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tctn3 in Genome Data Viewer
    Location:
    19 C3; 19 34.25 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40584890..40600768, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40596446..40612324, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 18 family, member A1 Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11675 Neighboring gene STARR-positive B cell enhancer ABC_E7650 Neighboring gene predicted gene, 27042 Neighboring gene STARR-positive B cell enhancer ABC_E1977 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene protein tyrosine phosphatase 4a1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365072.1NP_001352001.1  tectonic-3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK030156, AW491485, DQ278871
      Consensus CDS
      CCDS89390.1
      UniProtKB/TrEMBL
      A0A0R4J1W4
      Related
      ENSMUSP00000121760.2, ENSMUST00000132452.2
      Conserved Domains (1) summary
      pfam07773
      Location:78354
      DUF1619; Protein of unknown function (DUF1619)
    2. NM_026260.3NP_080536.2  tectonic-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080536.2

      Status: VALIDATED

      Source sequence(s)
      AC142101, AC166063
      Consensus CDS
      CCDS29804.1
      UniProtKB/Swiss-Prot
      Q8CDF3, Q8R2Q6, Q9CRC5
      Related
      ENSMUSP00000025981.9, ENSMUST00000025981.15
      Conserved Domains (1) summary
      pfam07773
      Location:78379
      DUF1619; Protein of unknown function (DUF1619)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      40584890..40600768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251056.2XP_030106916.1  tectonic-3 isoform X1

      Conserved Domains (1) summary
      pfam07773
      Location:1596
      DUF1619; Protein of unknown function (DUF1619)

    RNA

    1. XR_004940172.1 RNA Sequence

    2. XR_001782613.3 RNA Sequence

    3. XR_386503.2 RNA Sequence