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    Tasp1 taspase, threonine aspartase 1 [ Mus musculus (house mouse) ]

    Gene ID: 75812, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tasp1provided by MGI
    Official Full Name
    taspase, threonine aspartase 1provided by MGI
    Primary source
    MGI:MGI:1923062
    See related
    Ensembl:ENSMUSG00000039033 AllianceGenome:MGI:1923062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930485D02Rik
    Summary
    Predicted to enable identical protein binding activity and threonine-type endopeptidase activity. Predicted to be involved in positive regulation of DNA-templated transcription; protein maturation; and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in brain ventricle; branchial arch; head; and limb bud. Orthologous to human TASP1 (taspase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.1), CNS E18 (RPKM 2.2) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tasp1 in Genome Data Viewer
    Location:
    2 F3; 2 69.2 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (139675399..139908767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (139833479..140066847, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase, long chain base subunit 3 Neighboring gene STARR-seq mESC enhancer starr_05833 Neighboring gene STARR-seq mESC enhancer starr_05835 Neighboring gene STARR-seq mESC enhancer starr_05836 Neighboring gene isthmin 1, angiogenesis inhibitor Neighboring gene STARR-seq mESC enhancer starr_05837 Neighboring gene STARR-seq mESC enhancer starr_05838 Neighboring gene STARR-seq mESC enhancer starr_05839 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139750776-139750959 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139760469-139760763 Neighboring gene STARR-positive B cell enhancer mm9_chr2:139792158-139792459 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139867947-139868134 Neighboring gene STARR-positive B cell enhancer ABC_E4503 Neighboring gene STARR-seq mESC enhancer starr_05842 Neighboring gene ribosomal protein S19, pseudogene 7 Neighboring gene STARR-positive B cell enhancer ABC_E4504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139996213-139996396 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables threonine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables threonine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables threonine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    threonine aspartase 1
    Names
    taspase-1
    NP_001153112.1
    NP_001153113.1
    NP_001276540.1
    NP_780434.1
    XP_011238131.1
    XP_017174798.1
    XP_017174799.1
    XP_017174800.1
    XP_017174801.1
    XP_017174802.1
    XP_017174803.1
    XP_017174804.1
    XP_030108031.1
    XP_030108032.1
    XP_030108033.1
    XP_030108034.1
    XP_030108035.1
    XP_030108036.1
    XP_036018549.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159640.2NP_001153112.1  threonine aspartase 1 isoform a

      See identical proteins and their annotated locations for NP_001153112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK015624, BB791136, BC024597
      Consensus CDS
      CCDS16802.1
      UniProtKB/Swiss-Prot
      Q8R1G1, Q99JP3
      Related
      ENSMUSP00000105706.3, ENSMUST00000110079.9
      Conserved Domains (1) summary
      cd04514
      Location:42416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    2. NM_001159641.2NP_001153113.1  threonine aspartase 1 isoform b

      See identical proteins and their annotated locations for NP_001153113.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK015624, AK036512, AK132709, BB791136
      Consensus CDS
      CCDS50731.1
      UniProtKB/TrEMBL
      Q3UJT0
      Related
      ENSMUSP00000096907.4, ENSMUST00000099304.4
      Conserved Domains (1) summary
      cd04514
      Location:42379
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    3. NM_001289611.1NP_001276540.1  threonine aspartase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a 3' terminal exon which extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI662572, AK015624, AK050603, BB665115
      UniProtKB/Swiss-Prot
      Q8R1G1
      Conserved Domains (1) summary
      cd04514
      Location:42162
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    4. NM_175225.5NP_780434.1  threonine aspartase 1 isoform a

      See identical proteins and their annotated locations for NP_780434.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK015624, AK036512, BB791136
      Consensus CDS
      CCDS16802.1
      UniProtKB/Swiss-Prot
      Q8R1G1, Q99JP3
      Related
      ENSMUSP00000039546.3, ENSMUST00000046656.9
      Conserved Domains (1) summary
      cd04514
      Location:42416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    RNA

    1. NR_110350.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon and uses an alternate splice site in a internal exon, compare to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK015624, AK160983, BB791136
    2. NR_110351.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK015624, AK160983, BB791136
    3. NR_110352.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks an internal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK015624, AK132709, BB791136

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      139675399..139908767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319311.1XP_017174800.1  threonine aspartase 1 isoform X4

      Conserved Domains (1) summary
      cd04514
      Location:42393
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    2. XM_017319312.2XP_017174801.1  threonine aspartase 1 isoform X6

      Conserved Domains (1) summary
      cd04514
      Location:42349
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    3. XM_017319310.2XP_017174799.1  threonine aspartase 1 isoform X3

      Conserved Domains (1) summary
      cd04514
      Location:42402
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    4. XM_011239829.3XP_011238131.1  threonine aspartase 1 isoform X1

      Conserved Domains (1) summary
      cd04514
      Location:42439
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    5. XM_030252176.2XP_030108036.1  threonine aspartase 1 isoform X9

      Conserved Domains (1) summary
      cd04514
      Location:38230
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    6. XM_030252175.2XP_030108035.1  threonine aspartase 1 isoform X8

      Conserved Domains (1) summary
      cd04514
      Location:1260
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    7. XM_017319314.3XP_017174803.1  threonine aspartase 1 isoform X7

      Conserved Domains (1) summary
      cd04514
      Location:1297
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    8. XM_030252174.2XP_030108034.1  threonine aspartase 1 isoform X6

      Conserved Domains (1) summary
      cd04514
      Location:42349
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    9. XM_030252173.2XP_030108033.1  threonine aspartase 1 isoform X5

      UniProtKB/TrEMBL
      Q3UJT0
      Conserved Domains (1) summary
      cd04514
      Location:42379
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    10. XM_036162656.1XP_036018549.1  threonine aspartase 1 isoform X4

      Conserved Domains (1) summary
      cd04514
      Location:42393
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    11. XM_017319309.2XP_017174798.1  threonine aspartase 1 isoform X1

      Conserved Domains (1) summary
      cd04514
      Location:42439
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    12. XM_017319315.3XP_017174804.1  threonine aspartase 1 isoform X9

      Conserved Domains (1) summary
      cd04514
      Location:38230
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    13. XM_017319313.3XP_017174802.1  threonine aspartase 1 isoform X7

      Conserved Domains (1) summary
      cd04514
      Location:1297
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    14. XM_030252171.2XP_030108031.1  threonine aspartase 1 isoform X1

      Conserved Domains (1) summary
      cd04514
      Location:42439
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    15. XM_030252172.2XP_030108032.1  threonine aspartase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8R1G1, Q99JP3
      Conserved Domains (1) summary
      cd04514
      Location:42416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    RNA

    1. XR_866347.3 RNA Sequence

    2. XR_866346.3 RNA Sequence

    3. XR_003953732.1 RNA Sequence

    4. XR_001783198.2 RNA Sequence