U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Alox12e arachidonate lipoxygenase, epidermal [ Mus musculus (house mouse) ]

    Gene ID: 11685, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alox12eprovided by MGI
    Official Full Name
    arachidonate lipoxygenase, epidermalprovided by MGI
    Primary source
    MGI:MGI:1274790
    See related
    Ensembl:ENSMUSG00000018907 AllianceGenome:MGI:1274790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8-LOX; Aloxe; 12-LOX; e-LOX1; 12-LOX-e; Alox12-ps1; Alox12-ps2
    Summary
    Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in arachidonate metabolic process and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Is expressed in alimentary system; hemolymphoid system; integumental system; and respiratory system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 12.1), ovary adult (RPKM 7.2) and 3 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Alox12e in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70206436..70213545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70315610..70322720, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33048 Neighboring gene predicted gene, 40192 Neighboring gene arachidonate 15-lipoxygenase Neighboring gene STARR-seq mESC enhancer starr_29874 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29875 Neighboring gene STARR-seq mESC enhancer starr_29876 Neighboring gene proline, glutamic acid and leucine rich protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 12(S)-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonate 12(S)-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables arachidonate 15-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables linoleate 13S-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables linoleate 13S-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoxygenase pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type
    Names
    arachidonate (12S)-lipoxygenase, epidermal-type
    arachidonate 12-lipoxygenase, epidermal
    arachidonate 12-lipoxygenase, epidermal-type
    e(12S)-LOX
    linoleate (13S)-lipoxygenase
    NP_663717.1
    XP_006532097.1
    XP_006532098.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145684.2NP_663717.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type

      See identical proteins and their annotated locations for NP_663717.1

      Status: VALIDATED

      Source sequence(s)
      AK138743, AL596096, BX630350
      Consensus CDS
      CCDS24943.1
      UniProtKB/Swiss-Prot
      P55249, Q91YW6
      UniProtKB/TrEMBL
      Q5F2E4
      Related
      ENSMUSP00000019051.3, ENSMUST00000019051.3
      Conserved Domains (2) summary
      cd01753
      Location:2111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:169653
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70206436..70213545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532035.4XP_006532098.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X2

      See identical proteins and their annotated locations for XP_006532098.1

      Conserved Domains (2) summary
      cd01753
      Location:35143
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:193685
      Lipoxygenase
    2. XM_006532034.5XP_006532097.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X1

      See identical proteins and their annotated locations for XP_006532097.1

      Conserved Domains (2) summary
      cd01753
      Location:35144
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:194686
      Lipoxygenase