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    Rnft1 ring finger protein, transmembrane 1 [ Mus musculus (house mouse) ]

    Gene ID: 76892, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnft1provided by MGI
    Official Full Name
    ring finger protein, transmembrane 1provided by MGI
    Primary source
    MGI:MGI:1924142
    See related
    Ensembl:ENSMUSG00000020521 AllianceGenome:MGI:1924142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610013E23Rik
    Summary
    Predicted to enable ubiquitin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway and protein autoubiquitination. Predicted to be located in early endosome membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human RNFT1 (ring finger protein, transmembrane 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.6), limb E14.5 (RPKM 4.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Rnft1 in Genome Data Viewer
    Location:
    11 C; 11 51.82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86375483..86389833)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86484657..86499007)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5258 Neighboring gene predicted gene, 26439 Neighboring gene STARR-positive B cell enhancer ABC_E5259 Neighboring gene STARR-positive B cell enhancer ABC_E3003 Neighboring gene STARR-seq mESC enhancer starr_30268 Neighboring gene STARR-seq mESC enhancer starr_30269 Neighboring gene ribosomal protein S6 kinase, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_30270 Neighboring gene STARR-positive B cell enhancer ABC_E3004 Neighboring gene tubulin, delta 1 Neighboring gene predicted gene 9975

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNFT1
    Names
    RING finger and transmembrane domain-containing protein 1
    NP_084064.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029788.5NP_084064.1  E3 ubiquitin-protein ligase RNFT1

      See identical proteins and their annotated locations for NP_084064.1

      Status: PROVISIONAL

      Source sequence(s)
      AL604063
      Consensus CDS
      CCDS25200.1
      UniProtKB/Swiss-Prot
      Q3U649, Q80X62, Q9DCN7
      Related
      ENSMUSP00000020827.7, ENSMUST00000020827.7
      Conserved Domains (1) summary
      cd00162
      Location:335376
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86375483..86389833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)