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    Zcchc3 zinc finger, CCHC domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 67917, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zcchc3provided by MGI
    Official Full Name
    zinc finger, CCHC domain containing 3provided by MGI
    Primary source
    MGI:MGI:1915167
    See related
    Ensembl:ENSMUSG00000074682 AllianceGenome:MGI:1915167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810406K24Rik
    Summary
    Predicted to enable double-stranded DNA binding activity. Involved in several processes, including cellular response to exogenous dsRNA; defense response to virus; and positive regulation of type I interferon production. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; medulla oblongata basal plate mantle layer; skeleton; and ventral grey horn. Orthologous to human ZCCHC3 (zinc finger CCHC-type containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Zcchc3 in Genome Data Viewer
    Location:
    2 H1; 2 74.98 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152253875..152256711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152411956..152415044, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14164 Neighboring gene neurensin 2 Neighboring gene VISTA enhancer mm271 Neighboring gene SRY (sex determining region Y)-box 12 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152231818-152232119 Neighboring gene RIKEN cDNA 6820408C15 gene Neighboring gene predicted gene, 27343 Neighboring gene predicted gene, 39960

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of RIG-I signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type I interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger CCHC domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175126.5NP_780335.1  zinc finger CCHC domain-containing protein 3

      See identical proteins and their annotated locations for NP_780335.1

      Status: VALIDATED

      Source sequence(s)
      AL928568
      Consensus CDS
      CCDS16884.1
      UniProtKB/Swiss-Prot
      Q8BPK2
      Related
      ENSMUSP00000096813.4, ENSMUST00000099207.5
      Conserved Domains (1) summary
      COG5082
      Location:330383
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152253875..152256711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)